Invasive aspergillosis

This Phase 2 trial tests whether a new drug called EL219 (Turletricin) is safe and effective for early treatment of invasive mould infections in people with weakened immune systems, such as those who have had a bone marrow transplant. About 60 participants will receive either EL2…

This study tests a new medicine called fosmanogepix for adults with serious mold infections that are hard to treat. About 234 people will join, receiving either the new drug or standard care. The main goal is to see if fewer people die by day 42. The study is currently recruiting…

This study looks at people with a mix of two lung conditions caused by the fungus Aspergillus: chronic pulmonary aspergillosis and allergic bronchopulmonary aspergillosis. Researchers want to see if adding steroid pills to the standard antifungal drug itraconazole works better th…

This Phase 1 trial tests a new radioactive tracer called [18F]-Fluorocellobiose ([18F]FCB) for PET/CT scans. The goal is to see if it can help find invasive mold infections in the body. The study includes healthy volunteers and people with known fungal infections. Participants re…

This study aims to create and test a clinical prediction score called FUNGAL-P to help doctors identify fungal pneumonia early in adults who come to the hospital with pneumonia. Researchers will analyze medical records from past patients and then test the score on new patients to…

This study tests a new type of PET scan that uses a radioactive fungal component to see if it can light up areas of Aspergillus infection in the body. Ten adults with suspected invasive fungal infections will receive the scan. The goal is to see if this method can accurately loca…

This study aims to understand why some people get severe or unusual fungal infections due to immune system problems. Researchers will collect blood, tissue, and other samples from up to 1,200 participants over 25 years. No new treatments are being tested; the goal is to learn mor…

This study will collect medical information and samples from 300 cancer patients who have or are at risk for a serious fungal infection called mucormycosis. Researchers hope to learn more about how the infection develops and how to better diagnose and manage it. Participants will…

This study looks at whether measuring Aspergillus fumigatus DNA in blood or lung fluid can help predict outcomes in patients with invasive aspergillosis, a serious fungal lung infection. Researchers will track 100 adults to see if changes in PCR levels during treatment relate to …

This study monitors the immune system of 20 adults with serious mold infections (like Aspergillus) to see how their T cells respond. The goal is to find out which patients might benefit from adding immunotherapy to standard antifungal drugs. Researchers will measure immune checkp…

This study is trying to understand why some people with severe flu in the ICU develop a dangerous fungal lung infection called aspergillosis. Researchers will compare the immune systems of 45 flu patients and non-flu pneumonia patients in the ICU. They hope to find differences in…