Inborn organic aciduria
MONDO:0000688An inherited disorder that affects the metabolism of any acidic compound containing carbon in a covalent linkage.
Also known as: disorder of organic acid metabolism, organic acid metabolism disorder, inborn error of organic acid metabolic process, inborn organic acid metabolic process disorder, organic acidemia, organic aciduria, rare inborn error of organic acid metabolic process, inherited organic acidemia
29 clinical trials for this condition and its sub-types, 5 tagged with Inborn organic aciduria itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Inborn organic aciduria
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Classic organic aciduria 0 trials · 20 incl. sub-types
15 sub-types
- Propionic acidemia 8 trials Sub-types →
- 3-methylglutaconic aciduria 0 trials · 5 incl. sub-types Sub-types →
- Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency 4 trials Sub-types →
- Methylmalonic aciduria and homocystinuria 1 trial · 3 incl. sub-types Sub-types →
- Multiple carboxylase deficiency 0 trials · 3 incl. sub-types Sub-types →
- Isovaleric acidemia 2 trials
- Vitamin B12-responsive methylmalonic acidemia 0 trials · 2 incl. sub-types Sub-types →
- 3-hydroxy-3-methylglutaric aciduria 1 trial
- 3-methylcrotonyl-CoA carboxylase deficiency 0 trials · 1 incl. sub-types Sub-types →
- Beta-ketothiolase deficiency 1 trial
- 2-methylbutyryl-CoA dehydrogenase deficiency 0 trials
- 3-hydroxyisobutyric aciduria 0 trials
- 3-hydroxyisobutyryl-CoA hydrolase deficiency 0 trials
- Combined malonic and methylmalonic acidemia 0 trials
- Isobutyryl-CoA dehydrogenase deficiency 0 trials
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Methylmalonic acidemia 7 trials · 8 incl. sub-types
7 sub-types
- Methylmalonic aciduria due to methylmalonyl-CoA mutase deficiency 4 trials Sub-types →
- Methylmalonic aciduria and homocystinuria 1 trial · 3 incl. sub-types Sub-types →
- Vitamin B12-responsive methylmalonic acidemia 0 trials · 2 incl. sub-types Sub-types →
- Combined malonic and methylmalonic acidemia 0 trials
- Isolated methylmalonic aciduria cblD type 0 trials
- Methylmalonic acidemia due to methylmalonyl-CoA epimerase deficiency 0 trials
- Methylmalonic acidemia due to transcobalamin receptor defect 0 trials
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Maple syrup urine disease 2 trials · 4 incl. sub-types
9 sub-types
- Maple syrup urine disease type 1A 1 trial
- Maple syrup urine disease type 1B 1 trial
- Maple syrup urine disease type 2 1 trial
- Pyruvate dehydrogenase E3 deficiency 1 trial
- Classic maple syrup urine disease 0 trials
- Intermediate maple syrup urine disease 0 trials
- Intermittent maple syrup urine disease 0 trials
- Maple syrup urine disease, mild variant 0 trials
- Thiamine-responsive maple syrup urine disease 0 trials
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Glutaric acidemia type 3 0 trials
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Malonic aciduria 0 trials
Most studied deeper sub-types
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Frozen ovary tissue awakened to restore fertility in women with early menopause
Disease control CompletedThis study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…
Sponsor: The First Affiliated Hospital of Zhengzhou University • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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New medical food tolerability study for rare metabolic conditions
Disease control CompletedThis study looked at whether a special medical food called Express Plus is acceptable for children and adults with certain inherited metabolic disorders like PKU and maple syrup urine disease. Over 28 days, 28 participants tried the product and reported how well they liked it, ho…
Sponsor: Vitaflo International, Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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New registry tracks pregnancy in women with rare metabolic diseases
Knowledge-focused CompletedThis study created a registry of medical records from women with inborn errors of metabolism—rare conditions that affect how the body turns food into energy. Researchers collected data from past or current pregnancies and followed babies for one year after birth. The goal was to …
Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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New study reveals how kids with language delays learn vocabulary
Knowledge-focused CompletedThis study looked at how the way words sound (phonotactic probability) and how they are spelled (orthography) affect vocabulary learning in 23 children with low oral language skills (DLD). All children took part in the same 12-week program, which used real words to improve vocabu…
Sponsor: Arizona State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:34 UTC
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Medical records reveal clues to rare genetic disease in amish and mennonite populations
Knowledge-focused CompletedThis study looked back at the medical records of 38 people who have a specific genetic form of propionic acidemia, a rare metabolic disorder. The goal was to describe how the condition progresses over time, especially heart problems, and to create a better plan for preventive car…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC