Immunodeficiency disease

MONDO:0021094

Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.

Also known as: immuno-deficiency, immunodeficiency, immunodeficiency disorder, immunodeficiency syndrome

776 clinical trials for this condition and its sub-types, 55 tagged with Immunodeficiency disease itself.

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Where it sits in the disease tree

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Part of

↑ Hereditary disease (18187) ↑ Immune system disorder (12959)

Sub-types of Immunodeficiency disease

T-cell immunodeficiency 4 trials · 484 incl. sub-types
3 sub-types
- AIDS 463 trials
- Congenital T-cell immunodeficiency 0 trials · 13 incl. sub-types Sub-types →
- Idiopathic CD4-positive T-lymphocytopenia 6 trials
B cell deficiency 5 trials · 85 incl. sub-types
5 sub-types
- Agammaglobulinemia 16 trials · 52 incl. sub-types Sub-types →
- Hyperimmunoglobulin syndrome 0 trials · 33 incl. sub-types Sub-types →
- Selective immunoglobulin deficiency disease 1 trial · 4 incl. sub-types Sub-types →
- PAX5-related B lymphopenia and autism spectrum disorder 0 trials
- Immunoglobulin beta deficiency 0 trials
Myalgic encephalomeyelitis/chronic fatigue syndrome 73 trials
Combined immunodeficiency 3 trials · 57 incl. sub-types
33 sub-types
- Severe combined immunodeficiency 24 trials · 37 incl. sub-types Sub-types →
- Ataxia telangiectasia 11 trials Sub-types →
- Wiskott-Aldrich syndrome 10 trials
- X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection and neoplasia 2 trials
- Combined immunodeficiency due to CRAC channel dysfunction 1 trial Sub-types →
- Combined immunodeficiency due to ZAP70 deficiency 1 trial
- Non-SCID combined immunodeficiency 0 trials · 1 incl. sub-types Sub-types →
- IRF4-related combined immunodeficiency 0 trials
- MHC class I deficiency 0 trials Sub-types →
- NFATC1-related combined immunodeficiency 0 trials
- POLD3-related combined immunodeficiency 0 trials
- RAC2-related combined immunodeficiency-bronchiectasis-cancer-predisposing syndrome 0 trials Sub-types →
- Autosomal dominant combined immunodeficiency due to ERBIN deficiency 0 trials
- Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to IL6R deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency 0 trials
- Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency 0 trials
- Combined immunodeficiency due to CD3gamma deficiency 0 trials
- Combined immunodeficiency due to CTPS1 deficiency 0 trials
- Combined immunodeficiency due to GINS1 deficiency 0 trials
- Combined immunodeficiency due to MALT1 deficiency 0 trials
- Combined immunodeficiency due to OX40 deficiency 0 trials
- Combined immunodeficiency due to POLE2 deficiency 0 trials
- Combined immunodeficiency due to RELA haploinsufficiency 0 trials
- Combined immunodeficiency due to STK4 deficiency 0 trials
- Combined immunodeficiency due to TBX1 deficiency 0 trials
- Combined immunodeficiency due to dimerization defective IKAROS mutation 0 trials
- Combined immunodeficiency due to moesin deficiency 0 trials
- Combined immunodeficiency syndrome 0 trials Sub-types →
- Combined immunodeficiency with low Ig due to BCL10 deficiency 0 trials
- Combined immunodeficiency-hypogammaglobulinemia-skeletal anomalies syndrome due to IKBKA deficiency 0 trials
- Early-onset combined immunodeficiency with low ig due to dominant negative IKAROS mutation 0 trials
- Late-onset combined immunodeficiency due to ICOSL deficiency 0 trials
Complement deficiency 2 trials · 28 incl. sub-types
8 sub-types
- Atypical hemolytic-uremic syndrome 19 trials Sub-types →
- Classic complement early component deficiency 0 trials · 7 incl. sub-types Sub-types →
- Disorder of lectin complement activation pathway 0 trials · 1 incl. sub-types Sub-types →
- Complement factor I deficiency 0 trials
- Complement receptor deficiency 0 trials
- Immunodeficiency due to a classical component pathway complement deficiency 0 trials Sub-types →
- Immunodeficiency due to a late component of complement deficiency 0 trials Sub-types →
- Recurrent Neisseria infections due to factor D deficiency 0 trials
X-linked lymphoproliferative syndrome 7 trials · 11 incl. sub-types
2 sub-types
- X-linked lymphoproliferative disease due to XIAP deficiency 4 trials
- X-linked lymphoproliferative disease due to SH2D1A deficiency 2 trials
GATA2 deficiency with susceptibility to MDS/AML 5 trials · 8 incl. sub-types
2 sub-types
- Monocytopenia with susceptibility to infections 5 trials
- Deafness-lymphedema-leukemia syndrome 1 trial
Idiopathic CD4 lymphocytopenia 7 trials
IKBKG-related immunodeficiency with or without ectodermal dysplasia 0 trials · 4 incl. sub-types
3 sub-types
- Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome 4 trials
- Ectodermal dysplasia and immunodeficiency 1 0 trials
- Immunodeficiency 33 0 trials
Immunodeficiency due to selective anti-polysaccharide antibody deficiency 2 trials
IRF4-related immune disorder 1 trial
2 sub-types
- IRF4-related combined immunodeficiency 0 trials
- Immunodeficiency 131 0 trials
PTEN harmartoma tumor syndrome with immune disorder 1 trial
Immunodeficiency 23 1 trial
Immunodeficiency 31B 1 trial
DNAJC21-related Shwachman Diamond syndrome 0 trials
DOCK2 deficiency 0 trials
FADD-related immunodeficiency 0 trials
FASLG-related immunodeficiency 0 trials
FNIP1-associated syndrome 0 trials
Shwachman-Diamond syndrome 1 0 trials
TFRC-related combined immunodeficiency 0 trials
TNFRSF9-related immunodeficiency 0 trials
1 sub-type
- Immunodeficiency 109 with lymphoproliferation 0 trials
Wiskott-Aldrich syndrome 2 0 trials
Wiskott-Aldrich syndrome, autosomal dominant form 0 trials
Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome 0 trials
Chronic mucocutaneous candidiasis and connective tissue disease due to JNK1 haploinsufficiency 0 trials
Cryptosporidiosis-chronic cholangitis-liver disease syndrome 0 trials
Hatipoglu immunodeficiency syndrome 0 trials
Hypoproteinemia, hypercatabolic 0 trials
Immune deficiency due to impaired neutrophil phagocytosis and migration 0 trials
Immunodeficiency 101 (varicella zoster virus-specific) 0 trials
Immunodeficiency 102 0 trials
Immunodeficiency 106, susceptibility to viral infections 0 trials
Immunodeficiency 107, susceptibility to invasive staphylococcus aureus infection 0 trials
Immunodeficiency 112 0 trials
Immunodeficiency 113 with autoimmunity and autoinflammation 0 trials
Immunodeficiency 114, folate-responsive 0 trials
Immunodeficiency 115 with autoinflammation 0 trials
Immunodeficiency 117 0 trials
Immunodeficiency 118 0 trials
Immunodeficiency 119 0 trials
Immunodeficiency 11b with atopic dermatitis 0 trials
Immunodeficiency 121 with autoinflammation 0 trials
Immunodeficiency 122 0 trials
Immunodeficiency 123 with HPV-related verrucosis 0 trials
Immunodeficiency 125 0 trials
Immunodeficiency 126, susceptibility to 0 trials
Immunodeficiency 127 0 trials
Immunodeficiency 128 0 trials
Immunodeficiency 132b 0 trials
Immunodeficiency 133 with ectodermal dysplasia with or without peripheral neuropathy 0 trials
Immunodeficiency 134 (Epstein-Barr virus-specific) 0 trials
Immunodeficiency 14b, autosomal recessive 0 trials
Immunodeficiency 15a 0 trials
Immunodeficiency 35 0 trials
Immunodeficiency 45 0 trials
Immunodeficiency 53 0 trials
Immunodeficiency 57 0 trials
Immunodeficiency 60 0 trials
Immunodeficiency 62 0 trials
Immunodeficiency 63 with lymphoproliferation and autoimmunity 0 trials
Immunodeficiency 64 0 trials
Immunodeficiency 65, susceptibility to viral infections 0 trials
Immunodeficiency 66 0 trials
Immunodeficiency 67 0 trials
Immunodeficiency 69 0 trials
Immunodeficiency 70 0 trials
Immunodeficiency 72 with autoinflammation 0 trials
Immunodeficiency 74, COVID-19-related, X-linked 0 trials
Immunodeficiency 75 0 trials
Immunodeficiency 76 0 trials
Immunodeficiency 77 0 trials
Immunodeficiency 78 with autoimmunity and developmental delay 0 trials
Immunodeficiency 80 with or without congenital cardiomyopathy 0 trials
Immunodeficiency 81 0 trials
Immunodeficiency 82 with systemic inflammation 0 trials
Immunodeficiency 84 0 trials
Immunodeficiency 85 and autoimmunity 0 trials
Immunodeficiency 86 0 trials
Immunodeficiency 87 and autoimmunity 0 trials
Immunodeficiency 88 0 trials
Immunodeficiency 89 and autoimmunity 0 trials
Immunodeficiency 91 and hyperinflammation 0 trials
Immunodeficiency 92 0 trials
Immunodeficiency 93 and hypertrophic cardiomyopathy 0 trials
Immunodeficiency 95 0 trials
Immunodeficiency 96 0 trials
Immunodeficiency 97 with autoinflammation 0 trials
Immunodeficiency 98 with autoinflammation, X-linked 0 trials
Immunodeficiency 99 with hypogammaglobulinemia and autoimmune cytopenias 0 trials
Immunodeficiency due to CD25 deficiency 0 trials
Lymphoproliferative syndrome 1 0 trials
Primary immunodeficiency due to calcium channel deficiency 0 trials
Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency 0 trials
Pyogenic bacterial infections due to MyD88 deficiency 0 trials

Most studied deeper sub-types

Common variable immunodeficiency (29) Netherton syndrome (15) DiGeorge syndrome (11) T-B+ severe combined immunodeficiency due to gamma chain deficiency (10) Hyper-IgM syndrome (8) Syndromic agammaglobulinemia (7) Combined immunodeficiency due to DOCK8 deficiency (6) Immunodeficiency 14 (6) Severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency (6) Activated PI3K-delta syndrome (5) C1 inhibitor deficiency (5) Hyper-IgE syndrome (5) Bruton-type agammaglobulinemia (4) Omenn syndrome (4) Hyper-IgE recurrent infection syndrome 1, autosomal dominant (3) Hyper-IgM syndrome type 1 (3) Severe combined immunodeficiency due to DCLRE1C deficiency (3) Complement component 3 deficiency (2) Nezelof syndrome (2) Selective IgA deficiency disease (2)

Including sub-types (776) Tagged with Immunodeficiency disease (55)

Trials to join now! 34 Not yet recruiting 3 Not yet finished but already full! 8 Completed 9 Terminated 1

Immunodeficiency disease

Where it sits in the disease tree

Most studied deeper sub-types

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