Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
MONDO:0010580Immunodysregulation - polyendocrinopathy - enteropathy - X-linked (IPEX) syndrome is a severe congenital systemic autoimmune disease characterized by refractory diarrhea, endocrinopathies, cutaneous involvement, and infections.
Also known as: DMSD, IDDM-secretory diarrhea syndrome, IDDM-secretory diarrhoea syndrome, IPEX, X linked polyendocrinopathy, X-linked autoimmunity-allergic dysregulation syndrome, XLAAD, XPID
48 clinical trials for this condition and its sub-types, 10 tagged with Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome itself.
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Milder stem cell transplant shows promise for kids with immune disorders
Disease control OngoingThis study tests a stem cell transplant using a milder chemotherapy-like regimen to treat children and young adults (up to age 28) with various immune system disorders. The goal is to help the donor stem cells settle in the body with fewer side effects. The study involves 20 part…
Phase 2 • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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New stem cell approach could fix immune systems in kids
Disease control OngoingThis Phase II trial tests a stem cell transplant from unrelated or partially matched family donors for children and young adults with severe immune deficiencies. The stem cells are specially processed to remove certain immune cells, aiming to reduce complications. The goal is to …
Phase 2 • Sponsor: Children's Hospital of Philadelphia • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC