IDH-wildtype glioblastoma

This study compared standard radiation plus chemotherapy to radiation plus two immunotherapy drugs (ipilimumab and nivolumab) in 159 people with a newly diagnosed, aggressive brain cancer called MGMT-unmethylated glioblastoma. The goal was to see if the immunotherapy combination …

This early-phase trial tested an mRNA vaccine called CVGBM in 37 people with a fast-growing brain cancer called glioblastoma. Participants had already had surgery and radiation. The vaccine aims to train the immune system to attack remaining cancer cells. The main goal was to che…

This early-phase trial tested adding the targeted drug regorafenib to standard chemotherapy (temozolomide) with or without radiation for people with a newly diagnosed, aggressive type of brain cancer called glioblastoma. The study involved 21 participants and aimed to find the sa…

This study tests whether an artificial intelligence system called GliomaAI-GBM can detect a specific aggressive brain tumor (IDH wildtype glioblastoma) using routine MRI scans. Researchers will analyze previously collected, anonymized MRI data from 1,372 patients across 13 hospit…

This study looked at whether whole genome sequencing of recurrent glioblastoma tumors can uncover more targeted treatment options. Researchers analyzed tumor samples from 164 patients who had surgery for their first recurrence. The goal was to see if this detailed genetic testing…