Hypoplastic left heart syndrome
MONDO:0004933Hypoplastic left heart syndrome (HLHS) refers to the abnormal development of the left-sided cardiac structures, resulting in obstruction to blood flow from the left ventricular outflow tract. In addition, the syndrome includes underdevelopment of the left ventricle, aorta, and aortic arch, as well as mitral atresia or stenosis.
Also known as: HLHS
85 clinical trials for this condition and its sub-types, 10 tagged with Hypoplastic left heart syndrome itself.
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Sub-types of Hypoplastic left heart syndrome
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Hypoplastic left heart syndrome 1 0 trials
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Hypoplastic left heart syndrome 2 0 trials
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Heart stem cells show promise in kids with half a heart
Disease control CompletedThis study tested whether injecting a child's own heart stem cells during a planned surgery could help their heart work better. It involved 25 children with hypoplastic left heart syndrome, a condition where the left side of the heart is underdeveloped. The main goals were to see…
Phase 1 • Sponsor: Joshua M Hare • Aim: Disease control
Last updated Jun 27, 2026 08:13 UTC
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Could a gentler breathing machine protect young hearts and brains after surgery?
Knowledge-focused CompletedChildren with congenital heart disease often need a breathing machine after surgery, and the pressure it creates can affect blood flow to the brain. This study compares conventional ventilation with NAVA, a mode that works with the child's own breathing signals, in 30 children re…
Sponsor: St. Justine's Hospital • Aim: Knowledge-focused
Last updated Sep 21, 2026 18:00 UTC
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3D hearts and AR boost med student learning in heart defect study
Knowledge-focused CompletedThis study tested whether 3D-printed heart models or augmented reality (AR) help first-year medical students understand two rare heart defects better than traditional slide lectures. 26 students took a quiz before and after learning with one of the three methods. The goal was to …
Sponsor: Case Western Reserve University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC