Hypersensitivity reaction disease
MONDO:0000605An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
Also known as: allergic reaction, sensitive, sensitivity, hypersensitive, hypersensitivity, hypersensitivity reaction
1025 clinical trials for this condition and its sub-types, 32 tagged with Hypersensitivity reaction disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Hypersensitivity reaction disease
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Allergic disease 179 trials · 969 incl. sub-types
12 sub-types
- Atopic eczema 468 trials · 481 incl. sub-types Sub-types →
- Allergic respiratory disease 2 trials · 220 incl. sub-types Sub-types →
- Food allergy 115 trials
- Drug allergy 35 trials
- Eye allergy 2 trials · 20 incl. sub-types Sub-types →
- Atopic IgE-mediated allergic disorder 13 trials
- Venom allergy 12 trials
- Gastrointestinal allergy 0 trials · 5 incl. sub-types Sub-types →
- Alpha-gal syndrome 4 trials
- Allergic otitis media 0 trials Sub-types →
- Latex allergy 0 trials
- Vulvovaginitis, allergic seminal 0 trials
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Anaphylaxis 26 trials · 27 incl. sub-types
2 sub-types
- Exercise-induced anaphylaxis 0 trials · 1 incl. sub-types Sub-types →
- Idiopathic anaphylaxis 1 trial
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Type IV hypersensitivity disease 0 trials · 18 incl. sub-types
3 sub-types
- Autoimmune lymphoproliferative syndrome 11 trials · 12 incl. sub-types Sub-types →
- Cryoglobulinemia 3 trials Sub-types →
- Serum sickness 3 trials
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Hypersensitivity vasculitis 0 trials · 16 incl. sub-types
2 sub-types
- Immunoglobulin A vasculitis 16 trials
- Allergic cutaneous vasculitis 1 trial
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IgE responsiveness, atopic 9 trials
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Type III hypersensitivity disease 3 trials · 6 incl. sub-types
2 sub-types
- Serum sickness 3 trials
- Arthus reaction 0 trials
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Progestogen hypersensitivity 3 trials
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Pseudoallergy 0 trials
1 sub-type
- Drug pseudoallergy 0 trials
Most studied deeper sub-types
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New hope for kidney patients with Hard-to-Match immune systems
Disease control Stopped earlyThis study tested two drugs, daratumumab and belatacept, in 5 highly sensitized dialysis patients waiting for a kidney transplant. The goal was to safely reduce the antibodies that make it very hard to find a compatible donor kidney. The trial was stopped early, but it aimed to h…
Phase 2 • Sponsor: University Hospital, Grenoble • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Nickel allergy and knee surgery: no big difference found?
Knowledge-focused Stopped earlyThis study looked at whether people with nickel allergy do better with special nickel-free knee implants. Researchers compared standard implants to nickel-free ones in 9 patients with self-reported nickel sensitivity. The goal was to see if nickel allergy affects pain, function, …
Sponsor: Rush University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC