Hypersensitivity reaction disease
MONDO:0000605An immune system disease that has basis in dysregulation of the hypersensitivity reaction, an inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system.
Also known as: allergic reaction, sensitive, sensitivity, hypersensitive, hypersensitivity, hypersensitivity reaction
1022 clinical trials for this condition and its sub-types, 32 tagged with Hypersensitivity reaction disease itself.
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Sub-types of Hypersensitivity reaction disease
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Allergic disease 178 trials · 966 incl. sub-types
12 sub-types
- Atopic eczema 467 trials · 480 incl. sub-types Sub-types →
- Allergic respiratory disease 2 trials · 218 incl. sub-types Sub-types →
- Food allergy 115 trials
- Drug allergy 35 trials
- Eye allergy 2 trials · 20 incl. sub-types Sub-types →
- Atopic IgE-mediated allergic disorder 13 trials
- Venom allergy 12 trials
- Gastrointestinal allergy 0 trials · 5 incl. sub-types Sub-types →
- Alpha-gal syndrome 4 trials
- Allergic otitis media 0 trials Sub-types →
- Latex allergy 0 trials
- Vulvovaginitis, allergic seminal 0 trials
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Anaphylaxis 26 trials · 27 incl. sub-types
2 sub-types
- Exercise-induced anaphylaxis 0 trials · 1 incl. sub-types Sub-types →
- Idiopathic anaphylaxis 1 trial
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Type IV hypersensitivity disease 0 trials · 18 incl. sub-types
3 sub-types
- Autoimmune lymphoproliferative syndrome 11 trials · 12 incl. sub-types Sub-types →
- Cryoglobulinemia 3 trials Sub-types →
- Serum sickness 3 trials
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Hypersensitivity vasculitis 0 trials · 16 incl. sub-types
2 sub-types
- Immunoglobulin A vasculitis 16 trials
- Allergic cutaneous vasculitis 1 trial
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IgE responsiveness, atopic 9 trials
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Type III hypersensitivity disease 3 trials · 6 incl. sub-types
2 sub-types
- Serum sickness 3 trials
- Arthus reaction 0 trials
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Progestogen hypersensitivity 3 trials
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Pseudoallergy 0 trials
1 sub-type
- Drug pseudoallergy 0 trials
Most studied deeper sub-types
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Can a simple puff before surgery keep kids breathing safely?
Prevention Recruiting nowThis study tests whether inhaling a drug called penehyclidine hydrochloride before surgery can prevent breathing complications in children aged 3 to 7 who are at higher risk. The trial involves 204 kids undergoing minor eye surgery with sevoflurane anesthesia. Researchers will co…
Phase 4 • Sponsor: Sun Yat-sen University • Aim: Prevention
Last updated Jun 27, 2026 12:07 UTC
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Could a puff of inhaled epinephrine stop severe allergic reactions?
Symptom relief Recruiting nowThis study tests if inhaled epinephrine can quickly ease systemic allergic reactions that happen during allergy testing or treatment. About 100 people aged 12 and older with known allergies will take part. The goal is to see how fast symptoms improve, aiming for a safer and easie…
Phase 1 • Sponsor: Dr. George Luciuk • Aim: Symptom relief
Last updated Aug 12, 2026 00:00 UTC
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New study aims to take the fear out of allergy testing for children
Symptom relief Recruiting nowThis study tests whether child life services—special support to help kids cope with medical procedures—can reduce pain and fear during skin prick allergy tests. About 140 children aged 1-18 will either receive this extra support or standard care. Researchers will measure pain, ho…
Sponsor: Children's Hospital of Fudan University • Aim: Symptom relief
Last updated Jul 08, 2026 00:00 UTC
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Nasal spray vs. needle: new study tests easier allergy rescue
Symptom relief Recruiting nowThis study looks at the safety of a nasal spray called neffy compared to a standard epinephrine shot for treating allergic reactions. It involves 600 people aged 4 and older who have an allergic reaction during a food challenge or allergy shot session. The goal is to see if the s…
Phase 4 • Sponsor: ARS Pharmaceuticals, Inc. • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC
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New dental tech aims to ease pain for kids with sensitive teeth
Symptom relief Recruiting nowThis study compares two computer-assisted anesthesia methods—intraosseous and infiltration—to see which works better for children aged 6-12 with Molar-Incisor Hypomineralization (MIH), a condition causing sensitive teeth. Researchers will measure pain, stress, and heart rate in 3…
Sponsor: Ankara Yildirim Beyazıt University • Aim: Symptom relief
Last updated Jun 27, 2026 08:12 UTC
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Scientists seek clues on white blood cell behavior in allergies and parasites
Knowledge-focused Recruiting nowThis study aims to understand how and why eosinophils (a type of white blood cell) become active in conditions like allergies, asthma, and parasitic infections. Researchers will observe up to 800 people aged 1 to 100 with high eosinophil levels. No experimental treatments are giv…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Scientists hunt for hidden clues to drug reactions in the blood
Knowledge-focused Recruiting nowThis study aims to find new markers in the blood that appear during non-allergic drug infusion reactions. Healthy adults will receive the antibiotic vancomycin and have blood samples taken to measure drug levels and other substances. The goal is to better understand and predict t…
Phase 1/2 • Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Aug 07, 2026 00:00 UTC