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Hyperparathyroidism
MONDO:0001741Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.
Also known as: hyperparathyroidism
91 clinical trials for this condition and its sub-types, 8 tagged with Hyperparathyroidism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hyperparathyroidism
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Primary hyperparathyroidism 23 trials · 56 incl. sub-types
1 sub-type
- Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types Sub-types →
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Hereditary hyperparathyroidism 1 trial · 35 incl. sub-types
2 sub-types
- Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types Sub-types →
- Hyperparathyroidism, transient neonatal 0 trials
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Secondary hyperparathyroidism 19 trials · 32 incl. sub-types
2 sub-types
- Secondary hyperparathyroidism of renal origin 7 trials · 18 incl. sub-types Sub-types →
- Non-renal secondary hyperparathyroidism 0 trials
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Tertiary hyperparathyroidism 2 trials
Most studied deeper sub-types
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Can a single dose of zoledronic acid safely treat bone loss in dialysis patients?
Disease control Not yet recruitingThis trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…
Phase 1 • Sponsor: University of Campinas, Brazil • Aim: Disease control
Last updated Sep 12, 2026 00:00 UTC
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Purple potatoes put to the test: a Heart-Healthy superfood in the making?
Disease control Not yet recruitingThis trial investigates whether eating purple-fleshed potatoes daily for four weeks can improve blood pressure and other heart health markers in men with prehypertension. Participants will consume either purple or white potato puree in a crossover design, with measurements taken …
Sponsor: Instituto de Investigacion Nutricional, Peru • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Can a cheap arthritis drug shield kidneys from heart and bone damage?
Disease control Not yet recruitingThis study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…
Phase 2 • Sponsor: University of Texas Southwestern Medical Center • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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New study could change how Men's UTIs are treated
Disease control Not yet recruitingThis study tests whether a common antibiotic for women's UTIs, fosfomycin-trometamol, works well for men with urinary tract infections. Current treatments can have serious side effects and increase antibiotic resistance. The trial will enroll 138 men in primary care and monitor f…
Phase 3 • Sponsor: University Hospital, Rouen • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Dialysis drug showdown: which vitamin d works best?
Disease control Not yet recruitingThis study compares two vitamin D medications—doxercalciferol (given through a vein) and calcitriol (taken by mouth)—to see which is better at lowering parathyroid hormone levels in kidney dialysis patients. About 98 adults on dialysis with high parathyroid hormone will take part…
Sponsor: Chittagong Medical College • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Does better dialysis keep parathyroid hormone in check?
Knowledge-focused Not yet recruitingResearchers at Assiut University are studying how common secondary hyperparathyroidism is among people with end-stage kidney disease who receive hemodialysis three times a week. The study also checks whether the quality of dialysis, measured by standard clearance formulas, relate…
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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Parathyroid surgery may lower blood pressure hormone, study hopes to find out
Knowledge-focused Not yet recruitingThis study follows 400 adults with primary hyperparathyroidism who are scheduled for parathyroid surgery. Researchers will measure aldosterone, a hormone that helps control blood pressure, before surgery and at 3, 6, and 12 months after. They will also track blood pressure and us…
Sponsor: Central Hospital, Nancy, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Parathyroid surgery may improve life quality for kidney patients, study hints
Knowledge-focused Not yet recruitingThis study will examine how quality of life changes after parathyroid surgery in 60 adults with kidney failure and secondary hyperparathyroidism. Researchers will use a database to compare quality-of-life scores, anxiety, and depression before and after surgery. The goal is to be…
Sponsor: West China Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:37 UTC