Hyperparathyroidism
MONDO:0001741Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes.
Also known as: hyperparathyroidism
91 clinical trials for this condition and its sub-types, 8 tagged with Hyperparathyroidism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hyperparathyroidism
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Primary hyperparathyroidism 23 trials · 56 incl. sub-types
1 sub-type
- Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types Sub-types →
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Hereditary hyperparathyroidism 1 trial · 35 incl. sub-types
2 sub-types
- Familial primary hyperparathyroidism 1 trial · 35 incl. sub-types Sub-types →
- Hyperparathyroidism, transient neonatal 0 trials
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Secondary hyperparathyroidism 19 trials · 32 incl. sub-types
2 sub-types
- Secondary hyperparathyroidism of renal origin 7 trials · 18 incl. sub-types Sub-types →
- Non-renal secondary hyperparathyroidism 0 trials
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Tertiary hyperparathyroidism 2 trials
Most studied deeper sub-types
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Glow-in-the-Dark tool may make parathyroid surgery safer and faster
Symptom relief CompletedThis study tested a device called PTeye that uses near-infrared light to help surgeons spot parathyroid glands during surgery for hyperparathyroidism. The goal was to see if it could reduce the number of tissue samples sent to the lab and lower the risk of needing a second surger…
Sponsor: University of California, San Francisco • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Ultrasound first: could it replace radiation scans for parathyroid patients?
Knowledge-focused CompletedThis study tested whether using ultrasound as the first imaging step before parathyroid surgery can safely reduce the need for radiation-based scans. 99 adults with primary hyperparathyroidism were enrolled. Those with clear ultrasound results went straight to surgery; others had…
Sponsor: Odense University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC