Hypereosinophilic syndrome
MONDO:0015691Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage.
Also known as: HES, hypereosinophilic disease, hypereosinophilic disorder, hypereosinophilic syndrome, eosinophilia
57 clinical trials for this condition and its sub-types, 19 tagged with Hypereosinophilic syndrome itself.
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Sub-types of Hypereosinophilic syndrome
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Pulmonary eosinophilia 30 trials
1 sub-type
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1 sub-type
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Secondary hypereosinophilic syndrome 0 trials · 1 incl. sub-types
1 sub-type
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Eosinophilia-myalgia syndrome 0 trials
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Primary hypereosinophilic syndrome 0 trials
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Can an injected biologic cut steroid Flare-Ups in a Tough-to-Treat asthma complication?
Disease control Not yet recruitingResearchers are studying depemokimab, an injected biologic drug, in adults aged 18 to 75 who have allergic bronchopulmonary aspergillosis (ABPA) along with severe eosinophilic asthma. The study tracks how many asthma attacks need systemic steroids and whether participants' qualit…
Sponsor: Qianfoshan Hospital • Aim: Disease control
Last updated Sep 20, 2026 00:00 UTC
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Nasal spray could tame tough asthma Flare-Ups
Disease control Not yet recruitingThis Phase 2 trial tests AD17002, a nasal spray that aims to calm the immune system in people with moderate to severe eosinophilic asthma that is not well controlled by current treatments. About 126 adults will receive either the spray or a placebo for 3 months. Researchers will …
Phase 2 • Sponsor: Advagene Biopharma Co. Ltd. • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Hope for severe asthma: study tests if biologics can heal lungs
Knowledge-focused Not yet recruitingThis study looks at whether biologic therapy can reverse long-term lung damage in adults with severe asthma. Researchers will follow 150 patients and 50 healthy volunteers for two years, using advanced imaging and lung function tests. The goal is to see if treatment leads to 'cli…
Sponsor: Western University, Canada • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC