Hyperacute transplant rejection
MONDO:1010186A transplant rejection that appears in the first minutes following transplantation and occurs only in vascularized grafts. This very fast rejection is characterized by vessels thrombosis leading to graft necrosis. Hyperacute rejection is caused by the presence of antidonor antibodies existing in the recipient before transplantation. These antibodies induce both complement activation and stimulation of endothelial cells to secrete Von Willebrand procoagulant factor, resulting in platelet adhesion and aggregation. The result of these series of reactions is the generation of intravascular thrombosis leading to lesion formation and ultimately to graft loss.
6 clinical trials for this condition and its sub-types, 0 tagged with Hyperacute transplant rejection itself.
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Blood test may spot kidney transplant rejection without a biopsy
Diagnosis OngoingThis study tests whether a blood test measuring donor-derived cell-free DNA can reliably detect kidney transplant rejection. Researchers will compare the test results with kidney biopsy findings in 5,000 transplant recipients across multiple countries. The goal is to see if this …
Sponsor: Paris Translational Research Center for Organ Transplantation • Aim: Diagnosis
Last updated Sep 06, 2026 00:00 UTC
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AI may spot hidden kidney transplant rejection
Knowledge-focused OngoingThis study is developing an artificial intelligence (AI) system to analyze kidney biopsy images from transplant patients. The goal is to see if AI can accurately tell apart different types of rejection, measure how much damage the kidney has, and predict if rejection might come b…
Sponsor: Chen Dajin • Aim: Knowledge-focused
Last updated Aug 05, 2026 00:00 UTC