Hyper-IgE syndrome

MONDO:0018037

A condition that is characterized by elevated serum IgE, dermatitis, and respiratory infections.

Also known as: HIES, hyper-IgE recurrent infection syndrome, hyperimmunoglobulin E syndrome

66 clinical trials for this condition and its sub-types, 5 tagged with Hyper-IgE syndrome itself.

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Where it sits in the disease tree

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↑ Hyperimmunoglobulin syndrome (34)

Sub-types of Hyper-IgE syndrome

Netherton syndrome 16 trials
Combined immunodeficiency due to DOCK8 deficiency 6 trials
Hyper-IgE recurrent infection syndrome 1, autosomal dominant 3 trials
Autosomal dominant combined immunodeficiency due to ERBIN deficiency 0 trials
Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency 0 trials
Autosomal recessive combined immunodeficiency due to IL6R deficiency 0 trials
Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency 0 trials
Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency 0 trials
Hyper-IgE recurrent infection syndrome 3, autosomal recessive 0 trials
Hyper-IgE recurrent infection syndrome 4, autosomal recessive 0 trials
Hyper-IgE recurrent infection syndrome 4A, autosomal dominant 0 trials
Hyper-IgE recurrent infection syndrome 5, autosomal recessive 0 trials
Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections 0 trials
Immunodeficiency 94 with autoinflammation and dysmorphic facies 0 trials

Including sub-types (66) Tagged with Hyper-IgE syndrome (5)

Trials to join now! 4 Not yet finished but already full! 1

Could a common arthritis drug tame rare immune disease symptoms?

Disease control Recruiting now

This early study tests baricitinib, a drug already approved for other immune conditions, in 20 people with Job syndrome who also have lupus-like disease or eczema. Participants take the pill daily for 6 months. The main goal is to see if it is safe and tolerable, while also check…

Phase 1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control

Last updated Sep 21, 2026 20:00 UTC
Scientists dig into skin bugs to unlock eczema secrets

Knowledge-focused Recruiting now

This study looks at the tiny organisms living on our skin—like bacteria and fungi—and how they might differ in people with eczema (atopic dermatitis). Researchers will collect skin samples from healthy volunteers and patients aged 2 to 40 with moderate to severe eczema, as well a…

Sponsor: National Human Genome Research Institute (NHGRI) • Aim: Knowledge-focused

Last updated Sep 18, 2026 00:00 UTC
Scientists seek answers for rare immune disorder

Knowledge-focused Recruiting now

This study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused

Last updated Sep 02, 2026 00:00 UTC
Scientists seek clues to fungal infections in immune system study

Knowledge-focused Recruiting now

This study aims to understand why some people are more prone to fungal infections, especially from Candida yeast. Researchers will collect blood, saliva, urine, and tissue samples from people with immune disorders, their family members, and healthy volunteers. No treatment is giv…

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused

Last updated Aug 26, 2026 00:00 UTC

Hyper-IgE syndrome

Where it sits in the disease tree

Could a common arthritis drug tame rare immune disease symptoms?

Scientists dig into skin bugs to unlock eczema secrets

Scientists seek answers for rare immune disorder

Scientists seek clues to fungal infections in immune system study