Hyper-IgE recurrent infection syndrome 1, autosomal dominant
MONDO:0007818A condition of decreased or absent presence or activity of signal transducer and activator of transcription 3 protein. Deficiency of this protein is associated with hyper-IgE syndrome.
Also known as: hyper-IgE recurrent infection syndrome, hyperimmunoglobulin E-recurrent infection syndrome, AD hyperimmunoglobulin E syndrome, AD-HIES, Buckley syndrome, HIES autosomal dominant, HIES, autosomal dominant, JOB syndrome
44 clinical trials for this condition and its sub-types, 3 tagged with Hyper-IgE recurrent infection syndrome 1, autosomal dominant itself.
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Could a common arthritis drug tame rare immune disease symptoms?
Disease control Recruiting nowThis early study tests baricitinib, a drug already approved for other immune conditions, in 20 people with Job syndrome who also have lupus-like disease or eczema. Participants take the pill daily for 6 months. The main goal is to see if it is safe and tolerable, while also check…
Phase 1 • Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Sep 21, 2026 21:00 UTC
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Scientists launch major study to unravel mysteries of rare lung infections
Knowledge-focused Recruiting nowThis study aims to learn more about non-tuberculous mycobacterial (NTM) infections, which cause repeated lung and other organ infections. Researchers will study up to 1,000 participants to understand the genetics, symptoms, and best treatments for these infections. The study also…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 21, 2026 21:00 UTC
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Scientists seek answers for rare immune disorder
Knowledge-focused Recruiting nowThis study aims to learn more about Hyper IgE syndrome, a rare immune disorder that causes skin and lung infections. Researchers will follow 600 patients and their relatives over time, examining their health and genetics. The goal is to better understand the disease and improve c…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC