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Human African trypanosomiasis
MONDO:0005459A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.
Also known as: Africam sleeping sickness, African trypanosomiasis, sleeping sickness
4 clinical trials for this condition and its sub-types, 2 tagged with Human African trypanosomiasis itself.
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Browse by category →Sub-types of Human African trypanosomiasis
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Infection by Trypanosoma gambiense 3 trials
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Infection by Trypanosoma rhodesiense 0 trials
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NIH opens study to treat parasitic infections like malaria and worms
Disease control Recruiting nowThis study at the National Institutes of Health evaluates and treats people aged 3 and older with known or suspected parasitic infections, such as malaria, intestinal worms, and others. Participants receive standard medical care, not experimental treatments. The goal is to monito…
Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Disease control
Last updated Sep 18, 2026 00:00 UTC
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One pill may halt sleeping sickness spread
Disease control Recruiting nowThis trial tests whether giving a single dose of acoziborole to people who test positive for sleeping sickness antibodies, but show no active infection, can stop the disease from spreading in a community. Researchers will screen entire villages and treat all seropositive individu…
Phase 3 • Sponsor: Institute of Tropical Medicine, Belgium • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC