Human African trypanosomiasis
MONDO:0005459A parasitic disorder caused by protozoa of the Trypanosoma brucei species. It is transmitted by flies and is endemic in various regions of Sub-Saharan Africa. Signs and symptoms include fever, joint pain, headache, and significant swelling of the lymph nodes. If left untreated, the parasitic infection causes anemia, heart, kidney, and endocrine failure, and neurologic damage. Subsequently patients develop confusion, disruption of the sleep cycle, and mental deterioration. The infection may lead to coma and death.
Also known as: Africam sleeping sickness, African trypanosomiasis, sleeping sickness
4 clinical trials for this condition and its sub-types, 2 tagged with Human African trypanosomiasis itself.
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Browse by category →Sub-types of Human African trypanosomiasis
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Infection by Trypanosoma gambiense 3 trials
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Infection by Trypanosoma rhodesiense 0 trials
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One pill to cure sleeping sickness? new trial raises hopes
Cure CompletedThis study tested a single oral dose of acoziborole in 208 adults with sleeping sickness, a deadly parasitic disease. Participants took three tablets once and were monitored for 18 months. The goal was to see if this simple treatment could cure both early and late stages of the d…
Phase 2/3 • Sponsor: Drugs for Neglected Diseases • Aim: Cure
Last updated Jun 26, 2026 17:39 UTC
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One pill could change the fight against sleeping sickness in kids
Disease control CompletedThis study tested a single dose of the oral drug acoziborole in 35 children aged 1 to 14 with sleeping sickness (g-HAT). The goal was to see how the drug works in the body and if it is safe and effective. This simpler treatment could help control the disease in remote areas where…
Phase 2/3 • Sponsor: Drugs for Neglected Diseases • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC