Histiocytosis
MONDO:0002637A morphologic finding indicating tissue infiltration by non-neoplastic or neoplastic histiocytes.
Also known as: histiocytic infiltrate, histiocytic syndrome, histiocytic and dendritic cell neoplasms
74 clinical trials for this condition and its sub-types, 16 tagged with Histiocytosis itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Histiocytosis
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Langerhans cell histiocytosis 39 trials · 40 incl. sub-types
8 sub-types
- Langerhans cell histiocytosis specific to childhood 1 trial Sub-types →
- Langerhans cell histiocytosis specific to adulthood 0 trials Sub-types →
- Eosinophilic granuloma 0 trials Sub-types →
- Hand-Schuller-Christian disease 0 trials
- Multisystem langerhans cell histiocytosis 0 trials
- Pulmonary langerhans cell histiocytosis 0 trials
- Single-system multifocal langerhans cell histiocytosis 0 trials
- Unifocal langerhans cell histiocytosis 0 trials
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Non-Langerhans cell histiocytosis 1 trial · 39 incl. sub-types
15 sub-types
- Niemann-Pick disease 10 trials · 22 incl. sub-types Sub-types →
- Erdheim-Chester disease 14 trials
- Sinus histiocytosis with massive lymphadenopathy 11 trials Sub-types →
- Juvenile xanthogranuloma 4 trials
- Indeterminate dendritic cell tumor 1 trial
- Xanthogranuloma 1 trial Sub-types →
- Benign cephalic histiocytosis 0 trials
- Generalized eruptive histiocytosis 0 trials
- Hereditary progressive mucinous histiocytosis 0 trials
- Multicentric reticulohistiocytosis 0 trials
- Necrobiotic xanthogranuloma 0 trials
- Papular xanthoma 0 trials
- Progressive nodular histiocytosis 0 trials
- Sea-blue histiocyte syndrome 0 trials
- Xanthoma disseminatum 0 trials
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Malignant histiocytosis 3 trials
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ALK+ histiocytosis 0 trials
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Reticulohistiocytic granuloma 0 trials
Most studied deeper sub-types
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New hope for kids with rare cancers: targeted drug selpercatinib tested in phase 2 trial
Disease control OngoingThis phase 2 trial tests the drug selpercatinib in children and young adults (ages 1 to 21) with advanced cancers that have a specific genetic change called a RET alteration. The goal is to see if the drug can shrink tumors or stop them from growing. Only one participant has been…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 05, 2026 00:00 UTC
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Targeted drug shows promise for kids with Tough-to-Treat cancers
Disease control OngoingThis study tested the drug ensartinib in 13 children and young adults (ages 1–21) whose cancers had come back or did not respond to treatment and had specific ALK or ROS1 gene changes. The goal was to see if the drug could shrink or stop tumor growth. While the drug targets cance…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jul 12, 2026 00:00 UTC
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New hope for kids with rare cancers: targeted drug larotrectinib tested in small trial
Disease control OngoingThis phase 2 trial is testing the drug larotrectinib in children and young adults (ages 1 to 21) with advanced solid tumors, non-Hodgkin lymphoma, or histiocytic disorders that have a specific genetic change called an NTRK fusion. The cancers have either come back after treatment…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Promising combo aims to tame relapsed childhood cancers
Disease control OngoingThis study tests a daily combination of sirolimus, celecoxib, and low-dose chemotherapy in 46 children whose solid or brain tumors have returned or not responded to standard treatment. The goal is to see if this approach can shrink tumors or stop them from growing. While not a cu…
Phase 2 • Sponsor: Emory University • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Rare disease study probes hidden brain effects
Knowledge-focused OngoingThis study looks at how histiocytosis—a group of rare disorders—may affect memory, thinking, and brain structure. Researchers will test 13 adults with these conditions using thinking tasks and MRI scans. The goal is to better understand brain changes, not to provide treatment.…
Sponsor: Memorial Sloan Kettering Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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New disease found in drug users: researchers race to understand it
Knowledge-focused By invitation onlyThis observational study looks at a newly identified lung condition called histiocytosis in people who inject drugs. Researchers will study 30 patients to understand symptoms, diagnosis, and outcomes. They will also test new ways to detect a substance called polyvinylpyrrolidone …
Sponsor: Tampere University Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:26 UTC