High-grade neuroendocrine carcinoma of the cervix uteri
MONDO:0016276High-grade neuroendocrine carcinoma of the cervix uteri is a rare, aggressive, primary cervical neoplasm, originating from neuroendocrine cells present in the lining epithelium of the cervix, characterized, macroscopically, by usually large lesions, sometimes with a barrel-shaped appearance. Patients often present with abnormal vaginal bleeding or discharge, pelvic/abdominal pain, post-coital spotting and/or dysuria, while symptoms related to carcinoid syndrome are not frequent.
Also known as: high-grade neuroendocrine carcinoma of the uterine cervix, poorly differentiated neuroendocrine carcinoma of the cervix uteri, poorly differentiated neuroendocrine cervical carcinoma
2837 clinical trials for this condition and its sub-types, 4 tagged with High-grade neuroendocrine carcinoma of the cervix uteri itself.
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New radioactive drug targets tough cancers in early trial
Disease control Recruiting nowThis early-phase study tests a new radioactive drug, 225Ac-ETN029, in 116 adults with advanced DLL3-positive cancers like small cell lung cancer or neuroendocrine tumors. The main goal is to check safety and find the right dose, while also seeing if the drug can shrink tumors. Pa…
Phase 1 • Sponsor: Novartis Pharmaceuticals • Aim: Disease control
Last updated Sep 11, 2026 00:00 UTC
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Immunotherapy plus chemo shows promise for rare cervical cancer
Disease control Recruiting nowThis study is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy and radiation can help women with a rare and aggressive type of cervical cancer called small cell neuroendocrine carcinoma. About 45 women with early to advanced stages of the disease…
Phase 2 • Sponsor: Chang Gung Memorial Hospital • Aim: Disease control
Last updated Aug 19, 2026 00:00 UTC
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New registry aims to unlock secrets of rare cervical cancer
Knowledge-focused Recruiting nowThis study is creating a registry of 750 people with a rare and aggressive form of cervical cancer called neuroendocrine carcinoma. Researchers will collect information from medical records to learn more about the disease, how it is treated, and what happens to patients over time…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC