Hereditary hemophagocytic lymphohistiocytosis
MONDO:0015541An instance of hemophagocytic lymphohistiocytosis that is caused by an inherited genomic modification in an individual.
Also known as: familial hemophagocytic lymphohistiocytosis, genetic hemophagocytic lymphohistiocytosis, genetic hemophagocytic syndrome, primary hemophagocytic lymphohistiocytosis
57 clinical trials for this condition and its sub-types, 8 tagged with Hereditary hemophagocytic lymphohistiocytosis itself.
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Sub-types of Hereditary hemophagocytic lymphohistiocytosis
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Chediak-Higashi syndrome 9 trials
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Griscelli syndrome type 2 1 trial
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Hermansky-Pudlak syndrome 2 0 trials
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Hermansky-Pudlak syndrome 9 0 trials
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Engineered t cells with a kill switch aim to make stem cell transplants safer
Disease control OngoingThis study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…
Phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Suicide Gene-Equipped t cells aim to make stem cell transplants safer
Disease control OngoingThis trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…
Phase 1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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500 cancer Patients' records reviewed to tame immunotherapy side effects
Knowledge-focused OngoingThis study looks back at the medical records of 500 children and adults with cancer who received immunotherapy at the National Cancer Institute. The goal is to understand the side effects, like inflammation and immune reactions, that can happen with these treatments. By learning …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 02, 2026 00:00 UTC