Hereditary gingival fibromatosis
MONDO:0016070Hereditary gingival fibromatosis (HGF) is a rare benign, slowly progressive, non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent (or more rarely the primary) dentition or even at birth. It presents as a localized or generalized, smooth or nodular overgrowth of the gingival tissues of varying severity. It can be isolated, with autosomal dominant inheritance, or as part of a syndrome.
Also known as: autosomal dominant gingival fibromatosis, autosomal dominant gingival hyperplasia, hereditary gingival fibromatosis, hereditary gingival hyperplasia
23 clinical trials for this condition and its sub-types, 0 tagged with Hereditary gingival fibromatosis itself.
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Sub-types of Hereditary gingival fibromatosis
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Fibromatosis, gingival, 2 2 trials
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Fibromatosis, gingival, 1 0 trials
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Fibromatosis, gingival, 3 0 trials
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Fibromatosis, gingival, 4 0 trials
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Fibromatosis, gingival, 5 0 trials
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Fibromatosis, gingival, 6 0 trials
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New heart failure drug JK07 enters Mid-Stage trial
Disease control OngoingThis Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…
Phase 2 • Sponsor: Salubris Biotherapeutics Inc • Aim: Disease control
Last updated Jun 27, 2026 12:37 UTC
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Heart failure drug study pulled before it even started
Disease control CancelledThis study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…
Phase 2 • Sponsor: Salubris Biotherapeutics Inc • Aim: Disease control
Last updated Jun 27, 2026 12:32 UTC
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Your extracted tooth could save your jawbone for implants
Disease control By invitation onlyThis study tests whether a patient's own stored tooth can be used as a graft to preserve jawbone after tooth extraction. About 21 adults needing at least two teeth pulled will receive this treatment. The goal is to maintain bone width and height for better future dental implant p…
Sponsor: Istanbul Saglik Bilimleri University • Aim: Disease control
Last updated Jun 27, 2026 12:30 UTC
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AI and volunteers team up to fight gum disease in seniors
Disease control OngoingThis study tests whether personalized oral hygiene advice, delivered through an AI-powered mobile health app by trained volunteers, can improve gum health in older adults. Eighty-eight participants aged 60 and over from daycare centers in Hong Kong will receive bi-weekly advice b…
Sponsor: The University of Hong Kong • Aim: Disease control
Last updated Jun 27, 2026 12:25 UTC
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Dental AI learns from 150 patients in new data study
Knowledge-focused OngoingThis study gathers mouth pictures from 150 adults with different gum conditions to teach an AI system how to spot gum disease. Participants simply have their teeth and gums photographed with a special probe. No treatment or medication is involved—just data collection to improve f…
Sponsor: LuminX • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC
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3D-Printed short implants could offer new option for jawbone loss
Knowledge-focused By invitation onlyThis study follows 100 people who already have short, 3D-printed dental implants in the back of the upper or lower jaw. Researchers measure bone loss and other dental health markers over three years to see how well these implants hold up. The goal is to learn whether these specia…
Sponsor: University of Guarulhos • Aim: Knowledge-focused
Last updated Jul 19, 2026 00:00 UTC