Hemorrhagic disease
MONDO:0002243Spontaneous or near spontaneous bleeding caused by a defect in clotting mechanisms (blood coagulation disorders) or another abnormality causing a structural flaw in the blood vessels (hemostatic disorders).
Also known as: bleeding diathesis, bleeding disorder, bleeding predisposition, bleeding tendency
510 clinical trials for this condition and its sub-types, 108 tagged with Hemorrhagic disease itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Hemorrhagic disease
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Hemophilia A 180 trials
5 sub-types
- Severe hemophilia A 50 trials
- Moderately severe hemophilia A 4 trials
- Mild hemophilia A 2 trials
- Hemophilia A with vascular abnormality 0 trials
- Symptomatic form of hemophilia A in female carriers 0 trials
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Purpura 4 trials · 117 incl. sub-types
3 sub-types
- Thrombocytopenic purpura 8 trials · 116 incl. sub-types Sub-types →
- Hyperglobulinemic purpura 0 trials
- Purpura fulminans 0 trials Sub-types →
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Hemophilia B 84 trials · 91 incl. sub-types
4 sub-types
- Severe hemophilia B 9 trials
- Moderately severe hemophilia B 2 trials
- Mild hemophilia B 1 trial
- Symptomatic form of hemophilia B in female carriers 0 trials
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Vascular hemostatic disease 62 trials · 63 incl. sub-types
2 sub-types
- Cavernous hemangioma 1 trial Sub-types →
- Shwartzman phenomenon 0 trials
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Hereditary von Willebrand disease 18 trials · 29 incl. sub-types
5 sub-types
- Von Willebrand disease 3 9 trials
- Von Willebrand disease 2 4 trials · 5 incl. sub-types Sub-types →
- Von Willebrand disease 1 3 trials
- Von Willebrand disease, X-linked form 0 trials
- Platelet-type von Willebrand disease 0 trials
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Inherited bleeding disorder, platelet-type 6 trials · 26 incl. sub-types
28 sub-types
- Glanzmann thrombasthenia 8 trials Sub-types →
- Platelet-type bleeding disorder 10 8 trials
- Congenital thrombotic thrombocytopenic purpura 5 trials
- Macrothrombocytopenia and granulocyte inclusions with or without nephritis or sensorineural hearing loss 1 trial
- Bernard-Soulier syndrome 0 trials Sub-types →
- Ehlers-Danlos syndrome, fibronectinemic type 0 trials
- Quebec platelet disorder 0 trials
- Scott syndrome 0 trials
- Bleeding diathesis due to thromboxane synthesis deficiency 0 trials
- Bleeding disorder, platelet-type, 21 0 trials
- Bleeding disorder, platelet-type, 22 0 trials
- Bleeding disorder, platelet-type, 24 0 trials
- Bleeding disorder, platelet-type, 25 0 trials
- Cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder 0 trials
- Gray platelet syndrome 0 trials
- Platelet-type bleeding disorder 11 0 trials
- Platelet-type bleeding disorder 12 0 trials
- Platelet-type bleeding disorder 14 0 trials
- Platelet-type bleeding disorder 15 0 trials
- Platelet-type bleeding disorder 16 0 trials
- Platelet-type bleeding disorder 17 0 trials
- Platelet-type bleeding disorder 18 0 trials
- Platelet-type bleeding disorder 19 0 trials
- Platelet-type bleeding disorder 20 0 trials
- Platelet-type bleeding disorder 8 0 trials
- Platelet-type bleeding disorder 9 0 trials
- Platelet-type von Willebrand disease 0 trials
- Primary release disorder of platelets 0 trials
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Acquired hemophilia 2 trials · 8 incl. sub-types
3 sub-types
- Acquired hemophilia A 6 trials
- Acquired factor XI deficiency 0 trials
- Acquired hemophilia B 0 trials
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Factor VII deficiency 6 trials
2 sub-types
- Congenital factor VII deficiency 3 trials
- Acquired factor VII deficiency 0 trials
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Congenital fibrinogen deficiency 2 trials · 6 incl. sub-types
1 sub-type
- Familial dysfibrinogenemia 2 trials · 6 incl. sub-types Sub-types →
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3 sub-types
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Congenital vitamin K-dependent coagulation factors deficiency 0 trials · 4 incl. sub-types
5 sub-types
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Acquired von willebrand syndrome 3 trials
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Factor X deficiency 2 trials
2 sub-types
- Acquired factor X deficiency 1 trial
- Congenital factor X deficiency 0 trials
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Congenital factor XII deficiency 1 trial
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East Texas bleeding disorder 0 trials
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Alpha-2-plasmin inhibitor deficiency 0 trials
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Congenital factor V deficiency 0 trials
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Congenital factor XI deficiency 0 trials
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Congenital factor XIII deficiency 0 trials
2 sub-types
- Factor XIII, A subunit, deficiency of 0 trials
- Factor XIII, b subunit, deficiency of 0 trials
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Hemophilia B leyden 0 trials
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Inherited prekallikrein deficiency 0 trials
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Prothrombin deficiency 0 trials
2 sub-types
- Acquired prothrombin deficiency 0 trials
- Congenital prothrombin deficiency 0 trials
Most studied deeper sub-types
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Could a common blood thinner replace warfarin for LVAD patients?
Disease control Not yet recruitingThis study compares two blood thinners—apixaban (Eliquis) and warfarin (Coumadin)—in 460 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to see which drug better prevents strokes, pump clots, and serious bleeding. Participants must have had their…
Phase 3 • Sponsor: Columbia University • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Protein and saline mist may cut bleeding risk after tonsil removal
Disease control Not yet recruitingThis trial tests whether giving patients extra protein and saline mist after tonsillectomy helps them heal faster and avoid complications. Tonsil removal is common in children and adults, but it often causes pain, trouble swallowing, and a risk of bleeding. The researchers will c…
Phase 3 • Sponsor: Hospital Felicio Rocho • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Can a newer acid blocker outperform standard care for ulcer bleeding?
Disease control Not yet recruitingThis trial tests whether a newer acid-reducing drug, vonoprazan, is better than a double dose of the standard drug esomeprazole at preventing rebleeding in people who have had a bleeding stomach or intestinal ulcer treated with endoscopy. About 108 adults at high risk of rebleedi…
Sponsor: National Cheng-Kung University Hospital • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Could LVAD patients ditch aspirin? new trial aims to find out
Disease control Not yet recruitingThis study tests whether patients with a heart pump (LVAD) can safely stop taking aspirin while continuing warfarin. The goal is to reduce bleeding problems without increasing dangerous clots. About 370 participants will be randomly assigned to receive either aspirin or a placebo…
Phase 4 • Sponsor: China National Center for Cardiovascular Diseases • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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New combo procedure aims to fix heart rhythm and prevent stroke in one go
Disease control Not yet recruitingThis study will test a combined procedure in 150 people with atrial fibrillation (AFib) who are at risk for stroke. Doctors will use pulse field ablation to correct the heart's rhythm and then close off a small pouch in the heart (the left atrial appendage) to prevent blood clots…
Sponsor: Asklepios proresearch • Aim: Disease control
Last updated Jun 27, 2026 11:01 UTC
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New Ultrasound-Guided procedure could reduce bleeding risk in cirrhosis patients
Disease control Not yet recruitingThis study tests a new procedure using an endoscopic ultrasound to guide the injection of tiny particles into the spleen, reducing blood flow and lowering the risk of dangerous bleeding in people with liver cirrhosis. The goal is to see if this method is safer and more effective …
Sponsor: Qilu Hospital of Shandong University • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Can a simple drug make Weight-Loss surgery safer for heavier patients?
Disease control Not yet recruitingThis study tests whether giving tranexamic acid (TXA) through a vein during weight-loss surgery can reduce blood loss in patients with a very high body mass index (BMI over 45). About 128 high-risk adults will receive TXA or a placebo to see if it lowers the need for blood transf…
Sponsor: Ain Shams University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Can dry plasma save lives in the field? new trial aims to find out
Disease control Not yet recruitingThis study tests whether giving dry plasma to people with massive bleeding before they reach the hospital can improve survival. Researchers will compare dry plasma to standard fluids in 650 adults with signs of bleeding shock. The main goal is to see if more people survive the fi…
Phase 4 • Sponsor: Vastra Gotaland Region • Aim: Disease control
Last updated Jun 26, 2026 18:17 UTC
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AI second pair of eyes could speed up finding hidden bleeding
Diagnosis Not yet recruitingResearchers are testing an AI software tool called DSA-VDet v1.0 that highlights suspected bleeding on angiography images in real time. The trial enrolls adults with suspected acute bleeding in various body regions who need a digital subtraction angiography (DSA) procedure. Docto…
Sponsor: Zhongda Hospital • Aim: Diagnosis
Last updated Sep 19, 2026 00:00 UTC
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COVID-19 ECMO patients face bleeding and clot risks, new study investigates
Knowledge-focused Not yet recruitingThis study looks back at the medical records of 50 adult ICU patients with COVID-19 who needed a life-support machine called ECMO. The goal is to understand how often bleeding and dangerous blood clots happen, and how blood transfusions and blood thinners affect their care. The f…
Sponsor: Rigshospitalet, Denmark • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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New algorithm aims to reduce bleeding risks in heart surgery
Knowledge-focused Not yet recruitingThis study aims to create a simple blood test-based guide to help doctors manage bleeding during open heart surgery. Researchers will use leftover blood samples from 140 patients to see if a special test (thromboelastography) can better direct the use of blood products like plate…
Sponsor: Serkan Uckun • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:14 UTC
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Frailty may be key to predicting bleeding in elderly heart patients
Knowledge-focused Not yet recruitingThis study will enroll 850 adults over 65 who have had a heart attack (acute coronary syndrome). Researchers want to see if adding frailty measurements to standard risk scores improves the prediction of serious bleeding during the hospital stay and up to 6 months later. The goal …
Sponsor: Assiut University • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:37 UTC