Heart disorder
MONDO:0005267A disease involving the heart and/or pericardium.
Also known as: cardiac disease, disease of heart, disease or disorder of heart, disorder of heart, disorder of heart/pericardium, heart disease, heart disease or disorder, heart disorder
6782 clinical trials for this condition and its sub-types, 311 tagged with Heart disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Heart disorder
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Heart failure 1,354 trials · 1,681 incl. sub-types
4 sub-types
- Congestive heart failure 263 trials · 778 incl. sub-types Sub-types →
- Symptomatic heart failure 6 trials · 96 incl. sub-types Sub-types →
- Cardio-renal syndrome 18 trials
- High output heart failure 0 trials
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Cardiac rhythm disease 173 trials · 1,522 incl. sub-types
17 sub-types
- Atrial fibrillation 893 trials · 899 incl. sub-types Sub-types →
- Cardiac arrest 255 trials
- Ventricular tachycardia 123 trials · 135 incl. sub-types Sub-types →
- Atrial tachycardia 18 trials · 72 incl. sub-types Sub-types →
- Cardiac conduction defect 10 trials · 72 incl. sub-types Sub-types →
- Sudden cardiac arrest 72 trials
- Cardiogenetic rhythm disorder 2 trials · 68 incl. sub-types Sub-types →
- Ventricular fibrillation 36 trials · 63 incl. sub-types Sub-types →
- Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome 53 trials
- Sudden arrhythmia death syndrome 35 trials
- His bundle tachycardia 1 trial
- Torsade-de-pointes syndrome with short coupling interval 1 trial
- Cardiac conduction disease with or without cardiomyoopathy 0 trials Sub-types →
- Incessant infant ventricular tachycardia 0 trials
- Multifocal atrial tachycardia 0 trials
- Sino-auricular heart block 0 trials
- Sinoatrial node dysfunction and deafness 0 trials
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Coronary artery disorder 1,267 trials · 1,410 incl. sub-types
12 sub-types
- Intermediate coronary syndrome 97 trials
- Coronary stenosis 64 trials · 96 incl. sub-types Sub-types →
- Coronary atherosclerosis 78 trials · 92 incl. sub-types Sub-types →
- Nonobstructive coronary artery disease 28 trials
- Coronary thrombosis 14 trials
- Coronary vasospasm 4 trials · 11 incl. sub-types Sub-types →
- Coronary aneurysm 7 trials
- Coronary artery congenital malformation 3 trials · 4 incl. sub-types Sub-types →
- Postoperative ventricular dysfunction 4 trials
- Coronary artery disease, autosomal dominant, 1 1 trial
- Coronary artery disease, autosomal dominant 2 0 trials
- Fibromuscular dysplasia of the coronary arteries 0 trials
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Myocardial disorder 5 trials · 1,064 incl. sub-types
5 sub-types
- Myocardial infarction 370 trials · 612 incl. sub-types Sub-types →
- Myocardial ischemia 222 trials · 503 incl. sub-types Sub-types →
- Myocarditis 40 trials · 52 incl. sub-types Sub-types →
- Conduction system disorder 8 trials · 46 incl. sub-types Sub-types →
- Neoplasm of myocardium 0 trials Sub-types →
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Cardiomyopathy 155 trials · 823 incl. sub-types
12 sub-types
- Intrinsic cardiomyopathy 16 trials · 699 incl. sub-types Sub-types →
- Familial cardiomyopathy 2 trials · 219 incl. sub-types Sub-types →
- Tako-tsubo cardiomyopathy 16 trials
- Cardiomyopathy due to anthracyclines 16 trials
- Doxorubicin induced cardiomyopathy 7 trials
- Chagas cardiomyopathy 3 trials
- Extrinsic cardiomyopathy 3 trials Sub-types →
- Idiopathic cardiomyopathy 2 trials · 3 incl. sub-types Sub-types →
- Non-compaction cardiomyopathy 3 trials
- Keshan disease 0 trials
- Uhl anomaly 0 trials
- Autoimmune cardiomyopathy 0 trials Sub-types →
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Heart valve disorder 181 trials · 771 incl. sub-types
4 sub-types
- Aortic valve disorder 77 trials · 398 incl. sub-types Sub-types →
- Mitral valve disorder 48 trials · 198 incl. sub-types Sub-types →
- Tricuspid valve disorder 25 trials · 94 incl. sub-types Sub-types →
- Pulmonary valve disorder 3 trials · 26 incl. sub-types Sub-types →
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Cardiogenetic disease 3 trials · 618 incl. sub-types
73 sub-types
- Familial cardiomyopathy 2 trials · 219 incl. sub-types Sub-types →
- Atrial septal defect 45 trials · 78 incl. sub-types Sub-types →
- Postural orthostatic tachycardia syndrome 71 trials
- Cardiogenetic rhythm disorder 2 trials · 68 incl. sub-types Sub-types →
- Ventricular arrhythmias due to cardiac ryanodine receptor calcium release deficiency syndrome 53 trials
- Tetralogy of fallot 34 trials
- Patent ductus arteriosus 28 trials Sub-types →
- Ventricular septal defect 24 trials · 26 incl. sub-types Sub-types →
- Familial bicuspid aortic valve 6 trials · 21 incl. sub-types Sub-types →
- NOTCH1-related AOS spectrum disorder 0 trials · 16 incl. sub-types Sub-types →
- Alagille syndrome 15 trials Sub-types →
- DiGeorge syndrome 11 trials
- Hypoplastic left heart syndrome 10 trials Sub-types →
- CHARGE syndrome 4 trials Sub-types →
- Velocardiofacial syndrome 4 trials
- Supravalvular aortic stenosis 3 trials
- Dextro-looped transposition of the great arteries 2 trials Sub-types →
- Ellis-van Creveld syndrome 1 trial Sub-types →
- Coronary artery disease, autosomal dominant, 1 1 trial
- Dextrocardia 1 trial
- Inherited mitral valve disease 0 trials · 1 incl. sub-types Sub-types →
- Structural congenital heart disease, multiple types - GATA4 0 trials · 1 incl. sub-types Sub-types →
- 8q24.3 microdeletion syndrome 0 trials
- ACTC1-related distal arthrogryposis with congenital heart disease 0 trials
- ACTN2-related cardiac and skeletal myopathy 0 trials Sub-types →
- CHIME syndrome 0 trials
- COG1-congenital disorder of glycosylation 0 trials
- Ehlers-Danlos syndrome, cardiac valvular type 0 trials
- Ehlers-Danlos syndrome, musculocontractural type 0 trials Sub-types →
- GATA6-related congenital heart disease with or without pancreatic agenesis or neonatal diabetes 0 trials Sub-types →
- HAND1 related congenital heart defect 0 trials
- HAND2 related congenital heart defect 0 trials
- Holt-Oram syndrome 0 trials Sub-types →
- Hordnes Engebretsen Knudtson syndrome 0 trials
- LMNA-related cardiocutaneous progeria syndrome 0 trials
- Larsen-like syndrome, B3GAT3 type 0 trials
- MGAT2-congenital disorder of glycosylation 0 trials
- MYH-6 related congenital heart defects 0 trials
- PLD1-related congenital heart disease 0 trials
- Peters plus syndrome 0 trials
- RBFOX2-related congenital heart disorder 0 trials
- Sengers syndrome 0 trials
- TARP syndrome 0 trials
- TFAP2B-related congenital heart disease spectrum disorder 0 trials Sub-types →
- TNNT2-related cardiomyopathy 0 trials Sub-types →
- Alveolar capillary dysplasia with misalignment of pulmonary veins 0 trials
- Autosomal dominant intellectual disability-craniofacial anomalies-cardiac defects syndrome 0 trials
- Cardiac anomalies - developmental delay - facial dysmorphism syndrome 0 trials
- Cardiac conduction disease with or without cardiomyoopathy 0 trials Sub-types →
- Cardiac valvular dysplasia, X-linked 0 trials
- Congenital alveolar dysplasia due to FGF10 0 trials
- Congenital alveolar dysplasia due to TBX4 0 trials
- Congenital heart defects, multiple types, 2 0 trials
- Congenital heart defects, multiple types, 3 0 trials
- Congenital heart defects, multiple types, 5 0 trials
- Congenital heart defects, multiple types, 8, with or without heterotaxy 0 trials
- Congenital heart defects, multiple types, 9 0 trials
- Congenital vertebral-cardiac-renal anomalies syndrome 0 trials Sub-types →
- Coronary artery disease, autosomal dominant 2 0 trials
- Dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome 0 trials
- Familial atrial myxoma 0 trials
- Familial atrioventricular septal defect 0 trials Sub-types →
- Familial retinal arterial macroaneurysm 0 trials
- Fibromuscular dysplasia of the coronary arteries 0 trials
- Heart defects-limb shortening syndrome 0 trials
- Lethal left ventricular non-compaction-seizures-hypotonia-cataract-developmental delay syndrome 0 trials
- Mehta lewis patton syndrome 0 trials
- Patent ductus arteriosus-bicuspid aortic valve-hand anomalies syndrome 0 trials
- Pericardial effusion, chronic 0 trials
- Severe hypotonia-psychomotor developmental delay-strabismus-cardiac septal defect syndrome 0 trials
- Sinoatrial node dysfunction and deafness 0 trials
- Transketolase deficiency 0 trials
- Tricuspid atresia 0 trials
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Congenital heart disease 269 trials · 419 incl. sub-types
23 sub-types
- Heart septal defect 3 trials · 94 incl. sub-types Sub-types →
- Tetralogy of fallot 34 trials
- Syndromic congenital heart disease 0 trials · 31 incl. sub-types Sub-types →
- Patent ductus arteriosus 28 trials Sub-types →
- Persistent truncus arteriosus 8 trials Sub-types →
- Coronary artery congenital malformation 3 trials · 4 incl. sub-types Sub-types →
- Congenital pulmonary veins anomaly 0 trials · 3 incl. sub-types Sub-types →
- Dextro-looped transposition of the great arteries 2 trials Sub-types →
- Structural congenital heart disease, multiple types - GATA4 0 trials · 1 incl. sub-types Sub-types →
- ACTC1-related distal arthrogryposis with congenital heart disease 0 trials
- GATA5-related congenital heart defects 0 trials Sub-types →
- GATA6-related congenital heart disease with or without pancreatic agenesis or neonatal diabetes 0 trials Sub-types →
- HAND1 related congenital heart defect 0 trials
- HAND2 related congenital heart defect 0 trials
- PLD1-related congenital heart disease 0 trials
- RBFOX2-related congenital heart disorder 0 trials
- TFAP2B-related congenital heart disease spectrum disorder 0 trials Sub-types →
- Aortic valve atresia 0 trials
- Congenital heart defects, multiple types 0 trials Sub-types →
- Heart defects-limb shortening syndrome 0 trials
- Mehta lewis patton syndrome 0 trials
- Mitral atresia disorder 0 trials
- Tricuspid atresia 0 trials
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Cardiac ventricle disorder 4 trials · 406 incl. sub-types
2 sub-types
- Aortic valve disorder 77 trials · 398 incl. sub-types Sub-types →
- Postoperative ventricular dysfunction 4 trials
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Heart conduction disease 7 trials · 178 incl. sub-types
10 sub-types
- Postural orthostatic tachycardia syndrome 71 trials
- Atrioventricular block 57 trials · 63 incl. sub-types Sub-types →
- Sinoatrial node disorder 5 trials · 22 incl. sub-types Sub-types →
- Progressive familial heart block 0 trials · 19 incl. sub-types Sub-types →
- Brugada syndrome 10 trials Sub-types →
- Catecholaminergic polymorphic ventricular tachycardia 9 trials · 10 incl. sub-types Sub-types →
- Wolff-Parkinson-White syndrome 3 trials
- Short QT syndrome 1 trial Sub-types →
- NKX2.5-related congenital, conduction and myopathic heart disease 0 trials
- Sinoatrial block 0 trials
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Inflammation of heart layer 1 trial · 114 incl. sub-types
2 sub-types
- Endocarditis 51 trials · 61 incl. sub-types Sub-types →
- Myocarditis 40 trials · 52 incl. sub-types Sub-types →
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Cardiogenic shock 100 trials
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Coronary microvascular disorder 69 trials
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Endocardium disorder 0 trials · 61 incl. sub-types
3 sub-types
- Endocarditis 51 trials · 61 incl. sub-types Sub-types →
- Endocardial fibroelastosis 0 trials
- Neoplasm of endocardium 0 trials Sub-types →
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Pericardium disorder 2 trials · 36 incl. sub-types
3 sub-types
- Pericarditis 20 trials · 24 incl. sub-types Sub-types →
- Pericardial effusion 8 trials · 10 incl. sub-types Sub-types →
- Neoplasm of pericardium 0 trials Sub-types →
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Rheumatic heart disease 18 trials
4 sub-types
- Acute rheumatic heart disease 0 trials
- Rheumatic congestive heart failure 0 trials
- Rheumatic myocarditis 0 trials
- Rheumatic pericarditis 0 trials Sub-types →
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22q11.2 deletion syndrome 7 trials · 13 incl. sub-types
4 sub-types
- DiGeorge syndrome 11 trials
- Velocardiofacial syndrome 4 trials
- Chromosome 22q11.2 deletion syndrome, distal 0 trials
- Congenital unilateral hypoplasia of depressor anguli oris 0 trials
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Hypertensive heart disease 7 trials
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Heart neoplasm 3 trials · 7 incl. sub-types
10 sub-types
- Heart cancer 2 trials · 4 incl. sub-types Sub-types →
- Benign neoplasm of heart 0 trials Sub-types →
- Cardiac germ cell tumor 0 trials Sub-types →
- Familial atrial myxoma 0 trials
- Heart malignant hemangiopericytoma 0 trials
- Neoplasm of endocardium 0 trials Sub-types →
- Neoplasm of epicardium 0 trials Sub-types →
- Neoplasm of myocardium 0 trials Sub-types →
- Primary adult heart tumor 0 trials
- Primary pediatric heart tumor 0 trials
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PHACE syndrome 2 trials
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Carcinoid heart disease 2 trials
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Aortopulmonary window 1 trial
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Heart aneurysm 1 trial
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Myocardial rupture 1 trial
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Thomas syndrome 0 trials
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Cardiac tuberculosis 0 trials
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Cor biloculare 0 trials
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Polyvalvular heart disease syndrome 0 trials
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White forelock with malformations 0 trials
Most studied deeper sub-types
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New drug aims to shield kidneys during heart surgery
Disease control Stopped earlyThis study tests a single dose of ravulizumab given before heart surgery to see if it can prevent kidney damage and serious kidney problems in people with chronic kidney disease. About 736 adults will take part. The goal is to reduce the risk of major kidney events within 90 days…
Phase 3 • Sponsor: Alexion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Heart drug study halted early: what we know
Disease control Stopped earlyThis study tested an experimental drug called CRD-4730 in people with a rare inherited heart rhythm disorder (CPVT) that can cause dangerous fast heartbeats. Seven adults received two different doses of the drug and a placebo to check safety and how the body processes it. The stu…
Phase 2 • Sponsor: Cardurion Pharmaceuticals, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:38 UTC
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Blood filter during heart bypass may prevent organ damage, but trial stopped early
Disease control Stopped earlyThis study tested a device called Efferon LPS that filters blood during heart surgery when a heart-lung machine is used. The goal was to see if it could prevent multiple organ failure, especially kidney damage. Only 14 people took part before the study was stopped, so the results…
Sponsor: Efferon JSC • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Heart surgery recovery: can patients manage their own precautions?
Symptom relief Stopped earlyThis study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…
Sponsor: University of Chicago • Aim: Symptom relief
Last updated Jun 27, 2026 07:56 UTC
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New MRI technique could make heart procedures safer and faster
Knowledge-focused Stopped earlyThis study tests whether special low-energy MRI settings can make it safe to use guidewires during heart catheterization. Guidewires help position catheters but can heat up in standard MRI. Researchers will enroll 22 adults who need a right heart catheterization to see if this ap…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Jul 17, 2026 00:00 UTC
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Heart-Lung Machine's gut impact studied in small trial
Knowledge-focused Stopped earlyThis study aimed to see if the heart-lung machine used during heart surgery changes blood flow in the gut. Researchers checked blood flow under the tongue as a way to measure gut health. The study was stopped early and included only 21 adults having aortic valve replacement. It w…
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC