Hearing disorder

This study tests a new gene therapy called DB-OTO for children with hearing loss caused by changes in the otoferlin gene. The treatment is injected into the inner ear to help restore hearing. Up to 30 children and infants will take part to check safety and how well it works.

This study compares two common hearing screening methods—pure-tone audiometry and otoacoustic emissions—in over 13,000 preschool children. The goal is to determine which method is better at identifying hearing loss early, so children can get the help they need to avoid speech and…

This study tests whether hearing aids can improve quality of life in cancer patients who develop hearing loss from platinum-based chemotherapy. Fifty-two adults currently on such chemotherapy and with confirmed hearing loss will be randomly assigned to receive a hearing aid or st…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder (CAPD). About 344 participant…

Many blast-exposed veterans struggle to hear in noisy places even though their standard hearing tests are normal. This study tests whether a new fitting method called speech-based audiometry (SBA) makes low-gain hearing aids more effective than the usual approach. Eighty veterans…

This study aims to create a large collection of tissue samples from people with head and neck disorders, such as hearing loss, mouth diseases, and throat cancers. Researchers will use leftover surgical tissue and additional samples like blood, saliva, and cheek swabs to study the…

This study looks at how multiple sclerosis (MS) affects hearing. Researchers will test hearing and analyze spinal fluid from 30 adults with MS to see if hearing problems are linked to inflammation in the body. The goal is to better understand MS, not to test a new treatment.

This nationwide study aims to understand how hearing loss affects thinking, language, reading, and emotional wellbeing in 256 deaf or hard-of-hearing adolescents. Researchers will use tests and questionnaires to measure speech perception, cognitive skills, and school burnout. No …

This study tests if adults having awake ear surgery can hear short electrical pulses applied to a part of the inner ear. Researchers want to see if people can tell different frequencies apart. The results could help design better hearing implants. About 18 participants will be in…

This study collects leftover tissue samples and additional blood, saliva, and cheek swabs from up to 1,000 people with hearing, balance, smell, taste, voice, or speech disorders. The samples are stored in a biobank for researchers to study the biology of these conditions. No new …