Head and neck neoplasm
MONDO:0005586A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Also known as: craniocervical region neoplasm, craniocervical region neoplasm (disease), craniocervical region tumor, craniocervical region tumour, head and neck neoplasm, head and neck neoplasm (excluding central nervous system), head and neck tumor, head and neck tumour
3518 clinical trials for this condition and its sub-types, 79 tagged with Head and neck neoplasm itself.
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Sub-types of Head and neck neoplasm
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Head and neck cancer 638 trials · 2,010 incl. sub-types
16 sub-types
- Head and neck carcinoma 74 trials · 1,420 incl. sub-types Sub-types →
- Malignant tumor of neck 14 trials · 507 incl. sub-types Sub-types →
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Angiosarcoma of the scalp 0 trials
- Malignant carotid body paraganglioma 0 trials
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Neoplasm of neck 1 trial · 507 incl. sub-types
4 sub-types
- Malignant tumor of neck 14 trials · 507 incl. sub-types Sub-types →
- Benign neoplasm of neck 0 trials
- Cervical dermoid cyst 0 trials
- Cervical neuroblastoma 0 trials
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Neoplasm of oropharynx 3 trials · 280 incl. sub-types
2 sub-types
- Oropharynx cancer 150 trials · 280 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
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Nasopharyngeal neoplasm 37 trials · 226 incl. sub-types
3 sub-types
- Malignant tumor of nasopharynx 9 trials · 214 incl. sub-types Sub-types →
- Benign neoplasm of nasopharynx 0 trials
- Nasopharyngeal teratoma 0 trials
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Eye neoplasm 3 trials · 192 incl. sub-types
13 sub-types
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Uvea neoplasm 1 trial · 103 incl. sub-types Sub-types →
- Retina neoplasm 2 trials · 36 incl. sub-types Sub-types →
- Conjunctival tumor 1 trial · 23 incl. sub-types Sub-types →
- Benign neoplasm of eye 0 trials · 19 incl. sub-types Sub-types →
- Cornea neoplasm 0 trials · 17 incl. sub-types Sub-types →
- Eyelid neoplasm 3 trials · 7 incl. sub-types Sub-types →
- Intraocular medulloepithelioma 1 trial
- Ocular surface squamous neoplasia 1 trial
- Combined hamartoma of the retina and retinal pigment epithelium 0 trials
- Lacrimal gland neoplasm 0 trials Sub-types →
- Orbital leiomyoma 0 trials
- Ring dermoid of cornea 0 trials
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Skull neoplasm 0 trials · 161 incl. sub-types
7 sub-types
- Skull base neoplasm 12 trials · 124 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Paranasal sinus neoplasm 5 trials · 29 incl. sub-types Sub-types →
- Neoplasm of jaw 1 trial · 9 incl. sub-types Sub-types →
- Orbit neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Jugular foramen meningioma 0 trials
- Schwannoma of jugular foramen 0 trials
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Neoplasm of hypopharynx 0 trials · 100 incl. sub-types
3 sub-types
- Hypopharynx cancer 50 trials · 100 incl. sub-types Sub-types →
- Benign neoplasm of hypopharynx 0 trials Sub-types →
- Epiglottis neoplasm 0 trials Sub-types →
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Tumor of salivary gland 9 trials · 85 incl. sub-types
4 sub-types
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Neoplasm of major salivary gland 0 trials · 17 incl. sub-types Sub-types →
- Benign neoplasm of salivary gland 1 trial · 5 incl. sub-types Sub-types →
- Neoplasm of minor salivary gland 0 trials Sub-types →
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Nasal cavity and paranasal sinus neoplasm 0 trials · 44 incl. sub-types
1 sub-type
- Nasal cavity and paranasal sinus carcinoma 21 trials · 44 incl. sub-types Sub-types →
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Tongue neoplasm 2 trials · 35 incl. sub-types
2 sub-types
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Benign neoplasm of tongue 0 trials
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Lip neoplasm 1 trial · 15 incl. sub-types
2 sub-types
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Benign neoplasm of lip 0 trials
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Nasal cavity neoplasm 1 trial · 15 incl. sub-types
3 sub-types
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of nasal cavity 1 trial Sub-types →
- Nasal cavity inverting papilloma 0 trials
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Benign epithelial tumor of salivary glands 0 trials · 12 incl. sub-types
1 sub-type
- Pleomorphic adenoma 12 trials
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Recurrent respiratory papillomatosis 8 trials · 9 incl. sub-types
1 sub-type
- Laryngeal papillomatosis 1 trial
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Cranial nerve neoplasm 0 trials · 8 incl. sub-types
12 sub-types
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Abducens nerve neoplasm 0 trials
- Facial nerve neoplasm 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Hypoglossal nerve neoplasm 0 trials Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
- Spinal accessory nerve neoplasm 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
- Trochlear nerve neoplasm 0 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
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Tonsil neoplasm 0 trials · 8 incl. sub-types
2 sub-types
- Tonsil cancer 5 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of tonsil 0 trials Sub-types →
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Odontogenic neoplasm 0 trials · 5 incl. sub-types
4 sub-types
- Keratocystic odontogenic tumor 3 trials
- Ameloblastoma 2 trials Sub-types →
- Ameloblastic carcinoma 0 trials
- Calcifying epithelial odontogenic tumor 0 trials
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Ocular adnexal lymphoma 4 trials
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Malignant epithelial tumor of salivary glands 0 trials · 4 incl. sub-types
1 sub-type
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Ear neoplasm 0 trials · 3 incl. sub-types
5 sub-types
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- External ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Inner ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Neoplasm of middle ear 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of ear 0 trials Sub-types →
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Familial thyroglossal duct cyst 2 trials
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Buccal mucosa neoplasm 0 trials · 2 incl. sub-types
2 sub-types
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of buccal mucosa 0 trials Sub-types →
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Gingival neoplasm 0 trials · 2 incl. sub-types
3 sub-types
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Congenital epulis 0 trials
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Neoplasm of floor of mouth 0 trials · 2 incl. sub-types
2 sub-types
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of floor of mouth 0 trials
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Palatal neoplasm 0 trials · 2 incl. sub-types
4 sub-types
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Soft palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of hard palate 0 trials
- Benign neoplasm of soft palate 0 trials
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Head and neck paraganglioma 1 trial
4 sub-types
- Carotid body paraganglioma 0 trials Sub-types →
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Tympanic paraganglioma 0 trials
- Vagus nerve paraganglioma 0 trials
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Cavernous hemangioma of face 0 trials
1 sub-type
- Cavernous hemangioma of retina 0 trials
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Epignathus 0 trials
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Facial dermoid cyst 0 trials
2 sub-types
- Nasal dermoid cyst 0 trials
- Orbital dermoid cyst 0 trials
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Gasserian ganglion meningioma 0 trials
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Laryngeal neuroendocrine neoplasm 0 trials
1 sub-type
- Laryngeal small cell carcinoma 0 trials
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Laryngotracheal angioma 0 trials
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Lipoma of face 0 trials
1 sub-type
- Lipoma of the conjunctiva 0 trials
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Nasal ganglioglioma 0 trials
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Nasal glial heterotopia 0 trials
Most studied deeper sub-types
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New combo aims to boost immune attack on HPV-Driven head and neck cancer
Disease control Stopped earlyThis Phase 3 trial tests whether adding an experimental immunotherapy called PDS0101 to the standard drug pembrolizumab helps people with advanced HPV16-positive head and neck cancer live longer. About 252 participants will receive either the combination or pembrolizumab alone. T…
Phase 3 • Sponsor: PDS Biotechnology Corp. • Aim: Disease control
Last updated Sep 04, 2026 00:00 UTC
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Experimental drug combo for head and neck cancer shows early promise
Disease control Stopped earlyThis early-stage trial tested an experimental drug called xevinapant combined with standard chemotherapy and radiation in people with head and neck cancer who cannot take the usual drug cisplatin. The goal was to find the safest dose of xevinapant. The study was terminated early,…
Phase 1 • Sponsor: University of Chicago • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Targeted pill shows promise for rare lung cancer, but trial stopped early
Disease control Stopped earlyThis phase 3 study tested a new drug called pralsetinib against standard chemotherapy for people with a specific type of advanced lung cancer that has a RET gene fusion. The goal was to see if pralsetinib could better delay cancer growth. The trial was terminated early, so full r…
Phase 3 • Sponsor: Hoffmann-La Roche • Aim: Disease control
Last updated Jun 27, 2026 09:11 UTC
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Cancer drug cocktail trial for head and neck cancer ends early
Disease control Stopped earlyThis study tested a combination of the experimental drug magrolimab with cetuximab and either pembrolizumab or docetaxel in people with head and neck cancer that had come back or spread. Only 4 people enrolled before the trial was stopped early. The goal was to see if the combo c…
Phase 2 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Tiny study uses PET scans to track cancer drug in tumors
Knowledge-focused Stopped earlyThis early-phase study aimed to use PET imaging to track how a new drug (BI 754111) spreads in the body and reaches tumors in people with advanced non-small cell lung cancer or head and neck cancer. Only 8 participants were planned, and the study was terminated early. The main go…
Phase 1 • Sponsor: Boehringer Ingelheim • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC