Head and neck neoplasm
MONDO:0005586A benign or malignant neoplasm that affects the anatomic structures of the head and neck region. Representative examples of benign neoplasms include salivary gland pleomorphic adenoma and nasal cavity papilloma. Representative examples of malignant neoplasms include oral cavity squamous cell carcinoma, laryngeal squamous cell carcinoma, and salivary gland carcinoma.
Also known as: craniocervical region neoplasm, craniocervical region neoplasm (disease), craniocervical region tumor, craniocervical region tumour, head and neck neoplasm, head and neck neoplasm (excluding central nervous system), head and neck tumor, head and neck tumour
3518 clinical trials for this condition and its sub-types, 79 tagged with Head and neck neoplasm itself.
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Sub-types of Head and neck neoplasm
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Head and neck cancer 638 trials · 2,010 incl. sub-types
16 sub-types
- Head and neck carcinoma 74 trials · 1,420 incl. sub-types Sub-types →
- Malignant tumor of neck 14 trials · 507 incl. sub-types Sub-types →
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Angiosarcoma of the scalp 0 trials
- Malignant carotid body paraganglioma 0 trials
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Neoplasm of neck 1 trial · 507 incl. sub-types
4 sub-types
- Malignant tumor of neck 14 trials · 507 incl. sub-types Sub-types →
- Benign neoplasm of neck 0 trials
- Cervical dermoid cyst 0 trials
- Cervical neuroblastoma 0 trials
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Neoplasm of oropharynx 3 trials · 280 incl. sub-types
2 sub-types
- Oropharynx cancer 150 trials · 280 incl. sub-types Sub-types →
- Benign neoplasm of oropharynx 0 trials
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Nasopharyngeal neoplasm 37 trials · 226 incl. sub-types
3 sub-types
- Malignant tumor of nasopharynx 9 trials · 214 incl. sub-types Sub-types →
- Benign neoplasm of nasopharynx 0 trials
- Nasopharyngeal teratoma 0 trials
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Eye neoplasm 3 trials · 192 incl. sub-types
13 sub-types
- Ocular cancer 10 trials · 168 incl. sub-types Sub-types →
- Uvea neoplasm 1 trial · 103 incl. sub-types Sub-types →
- Retina neoplasm 2 trials · 36 incl. sub-types Sub-types →
- Conjunctival tumor 1 trial · 23 incl. sub-types Sub-types →
- Benign neoplasm of eye 0 trials · 19 incl. sub-types Sub-types →
- Cornea neoplasm 0 trials · 17 incl. sub-types Sub-types →
- Eyelid neoplasm 3 trials · 7 incl. sub-types Sub-types →
- Intraocular medulloepithelioma 1 trial
- Ocular surface squamous neoplasia 1 trial
- Combined hamartoma of the retina and retinal pigment epithelium 0 trials
- Lacrimal gland neoplasm 0 trials Sub-types →
- Orbital leiomyoma 0 trials
- Ring dermoid of cornea 0 trials
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Skull neoplasm 0 trials · 161 incl. sub-types
7 sub-types
- Skull base neoplasm 12 trials · 124 incl. sub-types Sub-types →
- Skull cancer 0 trials · 38 incl. sub-types Sub-types →
- Paranasal sinus neoplasm 5 trials · 29 incl. sub-types Sub-types →
- Neoplasm of jaw 1 trial · 9 incl. sub-types Sub-types →
- Orbit neoplasm 0 trials · 2 incl. sub-types Sub-types →
- Jugular foramen meningioma 0 trials
- Schwannoma of jugular foramen 0 trials
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Neoplasm of hypopharynx 0 trials · 100 incl. sub-types
3 sub-types
- Hypopharynx cancer 50 trials · 100 incl. sub-types Sub-types →
- Benign neoplasm of hypopharynx 0 trials Sub-types →
- Epiglottis neoplasm 0 trials Sub-types →
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Tumor of salivary gland 9 trials · 85 incl. sub-types
4 sub-types
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Neoplasm of major salivary gland 0 trials · 17 incl. sub-types Sub-types →
- Benign neoplasm of salivary gland 1 trial · 5 incl. sub-types Sub-types →
- Neoplasm of minor salivary gland 0 trials Sub-types →
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Nasal cavity and paranasal sinus neoplasm 0 trials · 44 incl. sub-types
1 sub-type
- Nasal cavity and paranasal sinus carcinoma 21 trials · 44 incl. sub-types Sub-types →
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Tongue neoplasm 2 trials · 35 incl. sub-types
2 sub-types
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Benign neoplasm of tongue 0 trials
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Lip neoplasm 1 trial · 15 incl. sub-types
2 sub-types
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Benign neoplasm of lip 0 trials
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Nasal cavity neoplasm 1 trial · 15 incl. sub-types
3 sub-types
- Nasal cavity cancer 5 trials · 14 incl. sub-types Sub-types →
- Benign neoplasm of nasal cavity 1 trial Sub-types →
- Nasal cavity inverting papilloma 0 trials
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Benign epithelial tumor of salivary glands 0 trials · 12 incl. sub-types
1 sub-type
- Pleomorphic adenoma 12 trials
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Recurrent respiratory papillomatosis 8 trials · 9 incl. sub-types
1 sub-type
- Laryngeal papillomatosis 1 trial
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Cranial nerve neoplasm 0 trials · 8 incl. sub-types
12 sub-types
- Malignant cranial nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Olfactory nerve neoplasm 0 trials · 4 incl. sub-types Sub-types →
- Optic nerve neoplasm 1 trial · 4 incl. sub-types Sub-types →
- Abducens nerve neoplasm 0 trials
- Facial nerve neoplasm 0 trials
- Glossopharyngeal nerve neoplasm 0 trials Sub-types →
- Hypoglossal nerve neoplasm 0 trials Sub-types →
- Oculomotor nerve neoplasm 0 trials Sub-types →
- Spinal accessory nerve neoplasm 0 trials
- Trigeminal nerve neoplasm 0 trials Sub-types →
- Trochlear nerve neoplasm 0 trials
- Vestibulocochlear nerve neoplasm 0 trials Sub-types →
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Tonsil neoplasm 0 trials · 8 incl. sub-types
2 sub-types
- Tonsil cancer 5 trials · 8 incl. sub-types Sub-types →
- Benign neoplasm of tonsil 0 trials Sub-types →
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Odontogenic neoplasm 0 trials · 5 incl. sub-types
4 sub-types
- Keratocystic odontogenic tumor 3 trials
- Ameloblastoma 2 trials Sub-types →
- Ameloblastic carcinoma 0 trials
- Calcifying epithelial odontogenic tumor 0 trials
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Ocular adnexal lymphoma 4 trials
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Malignant epithelial tumor of salivary glands 0 trials · 4 incl. sub-types
1 sub-type
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Ear neoplasm 0 trials · 3 incl. sub-types
5 sub-types
- Malignant ear neoplasm 0 trials · 2 incl. sub-types Sub-types →
- External ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Inner ear neoplasm 0 trials · 1 incl. sub-types Sub-types →
- Neoplasm of middle ear 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of ear 0 trials Sub-types →
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Familial thyroglossal duct cyst 2 trials
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Buccal mucosa neoplasm 0 trials · 2 incl. sub-types
2 sub-types
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of buccal mucosa 0 trials Sub-types →
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Gingival neoplasm 0 trials · 2 incl. sub-types
3 sub-types
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Benign neoplasm of gum 0 trials Sub-types →
- Congenital epulis 0 trials
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Neoplasm of floor of mouth 0 trials · 2 incl. sub-types
2 sub-types
- Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types Sub-types →
- Benign neoplasm of floor of mouth 0 trials
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Palatal neoplasm 0 trials · 2 incl. sub-types
4 sub-types
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Soft palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Benign neoplasm of hard palate 0 trials
- Benign neoplasm of soft palate 0 trials
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Head and neck paraganglioma 1 trial
4 sub-types
- Carotid body paraganglioma 0 trials Sub-types →
- Jugulotympanic paraganglioma 0 trials Sub-types →
- Tympanic paraganglioma 0 trials
- Vagus nerve paraganglioma 0 trials
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Cavernous hemangioma of face 0 trials
1 sub-type
- Cavernous hemangioma of retina 0 trials
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Epignathus 0 trials
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Facial dermoid cyst 0 trials
2 sub-types
- Nasal dermoid cyst 0 trials
- Orbital dermoid cyst 0 trials
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Gasserian ganglion meningioma 0 trials
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Laryngeal neuroendocrine neoplasm 0 trials
1 sub-type
- Laryngeal small cell carcinoma 0 trials
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Laryngotracheal angioma 0 trials
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Lipoma of face 0 trials
1 sub-type
- Lipoma of the conjunctiva 0 trials
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Nasal ganglioglioma 0 trials
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Nasal glial heterotopia 0 trials
Most studied deeper sub-types
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New hope for advanced HER2 cancers? drug trial launches
Disease control Not yet recruitingThis early-phase study tests a drug called zanidatamab in 10 adults with advanced HER2-positive solid tumors (like endometrial, bladder, or pancreatic cancer) that have worsened after at least one prior treatment. Participants receive the drug by IV every two weeks. The main goal…
Phase 2 • Sponsor: Haihua Yuan • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New drug targets hard-to-treat cancers in early trial
Disease control Not yet recruitingThis study tests a drug called Trastuzumab Rezetecan in 15 adults with advanced solid tumors that have the HER2 protein. The goal is to see if the drug can shrink tumors. Participants get the drug by IV every 3 weeks. This is for people whose cancer has worsened after other treat…
Phase 2 • Sponsor: Haihua Yuan • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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AI reads tumor slides to match cancer patients with trials
Diagnosis Not yet recruitingMany cancer trials require patients to have specific molecular markers, so researchers test large numbers of people to find the few who qualify. This study evaluates FATHOM, an AI system that reads clinical trial records and routine tumor slides to predict which patients carry th…
Sponsor: Harvard Medical School (HMS and HSDM) • Aim: Diagnosis
Last updated Sep 13, 2026 00:00 UTC
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Can light be the new shield against radiation mouth sores?
Prevention Not yet recruitingThis pilot study tests two light therapy devices—one placed inside the mouth and one outside—to prevent and treat painful mouth sores caused by radiation therapy. Sixty adults with oral cavity or oropharynx cancer will receive light sessions twice a week for prevention, then thre…
Sponsor: Centre Paul Strauss • Aim: Prevention
Last updated Jun 27, 2026 13:02 UTC
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Light therapy may soothe chemo mouth sores in children
Prevention Not yet recruitingThis study tests if a special light (photobiomodulation) can prevent and treat painful mouth sores caused by chemotherapy in children aged 4-17 with cancer. Half of the 49 participants will get light therapy, and the other half will get a standard gel. The goal is to see if the l…
Sponsor: Universidad de Guanajuato • Aim: Prevention
Last updated Jun 27, 2026 09:00 UTC
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Shorter radiation course tested for advanced head and neck cancer
Symptom relief Not yet recruitingResearchers compare two palliative radiation schedules for people with incurable head and neck cancer. The standard Split Course takes several weeks and often causes hard-to-tolerate side effects. The study tests whether a shorter Quad Shot regimen can shrink tumors and ease symp…
Sponsor: Instituto Nacional de Cancerologia, Columbia • Aim: Symptom relief
Last updated Sep 18, 2026 00:00 UTC
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Can a simple phone call after the ER get cancer patients treated faster?
Knowledge-focused Not yet recruitingThis pilot study will test whether trained community health navigators can help head and neck cancer patients get diagnosed and treated faster after an emergency room visit. The navigators will call or text patients to help with barriers like transportation, insurance, or housing…
Sponsor: University of Tennessee • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:12 UTC