Head and neck carcinoma

Researchers are testing whether giving tislelizumab, albumin paclitaxel, and cisplatin before surgery, followed by standard treatment, works better than standard treatment alone for people with locally advanced oral squamous cell carcinoma. The trial enrolls 134 participants with…

This early-phase study tests whether adding the experimental drug ipatasertib to standard chemotherapy and radiation is safe and effective for people with advanced head and neck cancer. Ipatasertib may help stop cancer cell growth. About 46 participants will receive the combinati…

This early-phase trial tests whether adding mild heat therapy (thermotherapy) to standard chemoradiation is safe and tolerable for people with advanced head and neck cancer. The heat, applied once a week, aims to make the cancer more sensitive to treatment. The study includes two…

This study tests whether giving lower doses of radiation to certain head and neck cancer patients can still effectively treat the cancer while causing fewer side effects. Participants receive chemotherapy and radiation, and doctors use a special PET scan to decide who can get the…

This study is testing whether taking the antibiotic metronidazole and using a chlorhexidine mouth rinse for 10 days before surgery can lower the amount of bacteria living inside oral cancer tumors. The researchers will compare bacteria levels before and after treatment in 30 adul…

This study tests whether a dietary supplement called HMB (beta-hydroxy-beta-methylbutyrate) can lower inflammation and improve recovery in people with head and neck cancer who are about to have surgery. Participants take either HMB or a placebo daily for 30 days before their oper…

This early-stage trial is testing a new drug called TGW101 in people with advanced solid tumors that have not responded to other treatments. TGW101 is given in two parts: an antibody-drug conjugate and a chemical trigger that activates it. The main goal is to check safety and fin…

This early-phase trial tests a combination of two newer drugs (tislelizumab and pamiparib) plus standard chemotherapy and re-radiation in 30 people whose head and neck cancer has come back. The main goal is to find a safe dose and check for side effects. Participants will be foll…

This study tests a new drug called HLX43 in people whose head and neck cancer has returned or spread to other parts of the body. The drug works by targeting a protein (PD-L1) on cancer cells to help the immune system attack them. About 167 adults aged 18 to 75 will take part to s…

This study tests a navigation system that helps surgeons remove head and neck tumors more precisely. During surgery, the system creates a 3D map of the tumor and its edges, which is then used to plan follow-up radiation therapy. The goal is to reduce the chance of leftover cancer…

This study tests an experimental drug called VMD-928, taken as a pill, either alone or with another cancer drug (pembrolizumab). It is for adults with advanced solid tumors or lymphoma that have not responded to or are no longer controlled by available treatments. The goal is to …

This study tests a new drug called SOA101, a special antibody that can attach to both cancer cells and immune cells to help the immune system attack tumors. It is for people with advanced solid tumors (like lung, ovarian, or breast cancer) who have no other standard treatment opt…

This early-stage trial tests a fluorescent dye attached to the cancer drug nivolumab. The dye is meant to make cancer cells glow during surgery, helping surgeons remove them more precisely. The study will enroll 40 people with head and neck cancer who are already scheduled for su…

This early study tests a new type of radiation therapy called ConformalFLASH, which delivers radiation at an ultra-high speed. It is for 10 adults with head and neck cancer who need a second round of radiation but cannot have surgery. The goal is to see if this fast treatment is …

This study tests whether a special geriatric assessment (PGA) and tailored support can reduce side effects and improve quality of life for older adults (60+) undergoing radiation for head and neck cancer, and for their family caregivers. About 36 participants will receive either …

This study compares giving cancer treatment at home versus in a clinic for 27 adults with various cancers in the Florida Panhandle. The goal is to see if home treatment is preferred and improves satisfaction, while also checking safety. Participants will receive their usual cance…

This study tests high-dose steroids (methylprednisolone or prednisone) in 35 head and neck cancer survivors who have nerve damage from past radiation. The goal is to find the best dose that improves symptoms like tongue weakness while limiting side effects. Participants must be a…

This study tests whether custom 3D-printed oral stents can reduce mouth sores in head and neck cancer patients receiving radiation therapy. The stents are made from a mold of the patient's mouth and cover teeth and gums during treatment. Researchers will compare sore rates and pa…

This study tests a personalized radiation therapy called PULSAR for people with head and neck cancer who cannot have or choose not to have standard treatment. The goal is to see if giving fewer, larger doses of radiation that adapt to changes in the body can better control tumors…

This study tests a simple technique called tongue-out radiation therapy (TORT) for people with head and neck cancer. By sticking out the tongue during treatment, the radiation dose to the mouth and throat may be lowered, potentially reducing painful side effects like trouble swal…

This study tests whether using a 3D mindfulness virtual reality headset can improve depression, anxiety, pain, and stress in head and neck cancer patients undergoing radiation or chemoradiation. Forty patients will be randomly assigned to either a 3D VR or a 2D non-immersive expe…

This study is testing whether a simple blood test that looks for tumor DNA can better detect any cancer left behind after radiation therapy for advanced head and neck cancer. Current scans often give false alarms, leading to unnecessary procedures. The study will enroll 63 adults…

This study looks at whether a simple blood test can find leftover cancer cells in people treated for advanced head and neck cancer. About 59 participants will give blood samples one and three months after finishing chemoradiotherapy. Researchers will compare the blood test result…

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study is collecting information on side effects from proton therapy in 5,000 adults with many types of cancer. Researchers will track both short-term and long-term side effects and link them to the details of each patient's treatment plan. The goal is to better predict who m…

This study tests a new program called Financial Compass that helps head and neck cancer patients deal with money problems caused by their illness. About 50 patients who are struggling financially will either get the program or usual care. The goal is to see if the program is prac…

This study looks at cells and biomarkers to understand why some head and neck cancers are more aggressive. Researchers will follow 50 newly diagnosed adults who have not yet received treatment. The goal is to learn more about how the cancer behaves, not to test a new treatment.

This study from Mayo Clinic aims to find biological markers (biomarkers) in blood, tissue, and saliva that can signal the presence or absence of HPV-related oropharyngeal cancer. Researchers will follow 560 participants, including patients with and without the disease, to see if …

This study looks at why people with head and neck cancer follow (or don't follow) swallowing exercises after radiation. Researchers will use blood tests and questionnaires to see if immune system proteins or feelings about the disease affect exercise habits. The goal is to find w…

This study is looking at how cancer genetic testing works in people from different ethnic backgrounds. Researchers will collect blood samples and genetic information from 1,800 adults with various solid tumors. The goal is to find cancer-related gene mutations and see if current …

This observational study aims to understand why metastatic adenoid cystic carcinoma (ACC) of the head and neck behaves differently in different people. Researchers will analyze stored tumor tissue and blood samples from 114 adults to see if certain biological types (ACC-I or ACC-…

This study is testing a new tool designed to predict side effects from cancer treatment in elderly patients (70+) with advanced head and neck cancer. The goal is to see if the tool can help doctors choose safer treatments. Only 3 participants are being enrolled, making this a ver…