GRIN-related complex neurodevelopmental disorder
MONDO:1060138A group of neurological and neurodevelopmental disorders caused by pathogenic variants in genes encoding subunits of the N-methyl-D-aspartate (NMDA) receptor, including GRIN1, GRIN2A, GRIN2B, and GRIN2D. These disorders are associated with a spectrum of symptoms such as developmental delay, intellectual disability, epilepsy, movement disorders, speech and language impairment, and neuropsychiatric features. The clinical presentation and severity vary depending on the specific gene and mutation involved.
3 clinical trials for this condition and its sub-types, 2 tagged with GRIN-related complex neurodevelopmental disorder itself.
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Browse by category →Sub-types of GRIN-related complex neurodevelopmental disorder
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5 sub-types
- GRIN2A-related developmental and/or epileptic encephalopathy with spike-wave activation in sleep 0 trials
- GRIN2A-related rolandic epilepsy-speech dyspraxia syndrome 0 trials
- GRIN2A-related self-limited epilepsy with centrotemporal spikes 0 trials
- Landau-Kleffner syndrome 0 trials
- Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation 0 trials
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2 sub-types