Grade III meningioma

This study tests a higher dose of a precise type of radiation called proton therapy for people with aggressive meningiomas (brain tumors). The goal is to find a safe dose that can better control the tumor after surgery. The study includes 21 participants with either grade II or g…

This study is for people with a rare, aggressive brain tumor called high-grade meningioma that has come back after radiation. It tests whether adding immunotherapy drugs (nivolumab with or without ipilimumab) to precise, high-dose radiation can help shrink the tumor or slow its g…

This study tested the immunotherapy drug pembrolizumab in 26 people with high grade meningioma that came back or remained after treatment. The goal was to see if the drug could stop the tumor from growing for at least 6 months. Participants received pembrolizumab and had regular …

This phase II trial tests whether combining stereotactic radiosurgery (precise, high-dose radiation) with the immunotherapy drug pembrolizumab (Keytruda) can help control recurrent meningioma, a type of brain tumor. The study enrolls 35 adults whose tumors have returned after pri…

This early-phase trial tests whether giving higher doses of radiation, guided by special PET/MRI scans, is safe for people with high-risk meningiomas (aggressive or recurrent brain tumors). About 24 adults will receive one of four radiation dose levels to find the highest dose th…