Grade III meningioma

This study tests an experimental drug called NEO100 in people with a fast-growing type of brain tumor called high-grade meningioma that remains after surgery, has progressed, or returned. About 30 participants will take NEO100 four times daily in 28-day cycles. The main goal is t…

This study tests an oral drug called JZP3507 (ONC206) in 30 adults with recurrent grade 2 or 3 meningioma, a type of brain tumor. Participants take the drug three days a week in 28-day cycles. The main goal is to see if the drug can shrink tumors, with safety and response duratio…

This phase IIb trial tests whether combining the drug everolimus with a targeted radiation therapy (177Lu-DOTATATE) can slow tumor growth in people with grades 2 and 3 meningioma that no longer responds to surgery or radiation. About 28 adults will receive the combination for 7 m…

This study tests a radioactive drug called Lutathera for people with a type of brain tumor (meningioma) that cannot be removed by surgery and has continued to grow after radiation therapy. The drug is given through a vein and targets tumor cells to stop them from growing. The tri…

This study tests whether the drug abemaciclib can help people with a fast-growing type of brain tumor called grade 3 meningioma. Participants will receive either the drug or a placebo after standard radiation therapy. The goal is to see if the drug delays tumor growth. About 72 p…

This study tests a shorter course of high-dose proton radiation for people with non-cancerous brain tumors like meningiomas and schwannomas. The goal is to see if fewer treatments can still control tumor growth while reducing side effects and being more convenient. About 70 adult…