Gliosarcoma

This study tests a combination of laser heat therapy (LITT) and the immunotherapy drug pembrolizumab in 32 adults with recurrent glioblastoma, an aggressive brain cancer. The laser heats and destroys hard-to-reach tumors, while pembrolizumab helps the immune system fight cancer c…

This phase 1 trial tests a genetically engineered virus called C134, made from a herpes simplex virus, in people with recurrent malignant glioma, a type of brain cancer. The virus is injected directly into the tumor, where it aims to infect and kill cancer cells while also trigge…

This study compared standard radiation plus chemotherapy to radiation plus two immunotherapy drugs (ipilimumab and nivolumab) in 159 people with a newly diagnosed, aggressive brain cancer called MGMT-unmethylated glioblastoma. The goal was to see if the immunotherapy combination …

This phase 2 trial tested whether adding two immunotherapy drugs (nivolumab and ipilimumab) to standard chemotherapy (temozolomide) improves survival in 47 adults with newly diagnosed glioblastoma or gliosarcoma. Participants had their tumors surgically removed and completed init…

This pilot study tested whether it's possible to quickly create and start a personalized drug combination for each patient with recurrent glioblastoma, a serious brain cancer. Researchers used genetic testing on tumor tissue to pick drugs that target specific mutations. The study…

This study tested giving a second round of radiation to people whose glioblastoma (a fast-growing brain tumor) came back after standard treatment. Seventeen adults aged 18 to 50 received daily radiation for 2-3 weeks. The goal was to find the safest highest dose and see how it af…

This phase 2 trial tested a combination of two drugs (retifanlimab and epacadostat) plus radiation and bevacizumab in 51 patients with recurrent glioblastoma, an aggressive brain cancer. The goal was to boost the immune system's attack on the tumor and improve survival. The study…

This study tested whether adding whole brain radiation and a drug called plerixafor to the usual chemotherapy and radiation could help people with a fast-growing brain tumor called glioblastoma. 21 patients took part. The goal was to see if the combination could delay tumor growt…

This early-phase trial tested the safety of adding two drugs, pembrolizumab and vorinostat, to standard chemotherapy and radiation for people newly diagnosed with glioblastoma, an aggressive brain cancer. The study enrolled 21 participants to find the highest safe dose of vorinos…

This study tested whether adding the immunotherapy drug atezolizumab to standard chemotherapy and radiation helps people with newly diagnosed glioblastoma, an aggressive brain cancer. About 60 participants received the combination to see if it improves survival and controls the d…

This early-stage trial tested whether adding chlorpromazine, an old antipsychotic drug, to standard treatment (radiation and chemotherapy) is safe for people newly diagnosed with glioblastoma, an aggressive brain cancer. Ten adults took part. The main goal was to find a safe dose…

This pilot study tested whether ramipril, a drug typically used for high blood pressure, can help prevent memory loss in people with glioblastoma who are receiving brain radiation. 75 patients took ramipril daily during and after chemoradiation. Researchers measured memory and th…

This pilot study tested whether a special PET scan using 18F-FDOPA can help doctors better plan surgery and radiation for people with newly diagnosed brain tumors (gliomas). Twenty-four adults took part at Mayo Clinic. The goal was to see if the scan provides useful information b…