Giant cell glioblastoma
MONDO:0016682A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO)
Also known as: Monstrocellular sarcoma [obs]
2892 clinical trials for this condition and its sub-types, 7 tagged with Giant cell glioblastoma itself.
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Experimental combo targets Hard-to-Treat brain cancers
Disease control OngoingThis early-stage study tested the safety and best dose of vorinostat when given with the chemotherapy drug temozolomide in 83 adults with aggressive brain tumors called malignant gliomas. The goal was to see if adding vorinostat could make the tumor cells more sensitive to chemot…
Phase 1 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Cancer cell therapy trial for brain tumor withdrawn before starting
Disease control CancelledThis study planned to test a new treatment combining CYNK-001 (natural killer cells from donated cord blood) with interleukin-2 in adults whose glioblastoma had returned and could be surgically removed. The goal was to see if this combination was safe and could extend the time be…
Phase 1/2 • Sponsor: Celularity Incorporated • Aim: Disease control
Last updated Jun 27, 2026 13:05 UTC
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New brain cancer drug shows promise in early trial
Disease control PausedThis early-phase study tests whether adding a drug called S-Gboxin to standard treatment can help people with glioblastoma, a fast-growing brain cancer. The drug works by cutting off the energy supply to cancer cells. Ten patients with recurrent or progressive disease will receiv…
Phase 1 • Sponsor: Petrov, Andrey • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Experimental virus therapy for childhood brain tumors tested with radiation
Disease control CancelledThis study aimed to test an experimental virus therapy called G207, combined with a single dose of radiation, in children whose high-grade glioma had come back after prior treatment. The virus was injected directly into the brain tumor to kill cancer cells and trigger an immune r…
Phase 2 • Sponsor: Pediatric Brain Tumor Consortium • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC