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Germ cell tumor
MONDO:0005040A benign or malignant, gonadal or extragonadal neoplasm that originates from germ cells. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor.
Also known as: germ cell neoplasm, germ cell tumor, neoplasm of germ cell, neoplasm of the germ cell, tumor of germ cell, tumor of the germ cell, tumour of germ cell, tumour of the germ cell
1542 clinical trials for this condition and its sub-types, 57 tagged with Germ cell tumor itself.
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Sub-types of Germ cell tumor
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Malignant germ cell tumor 14 trials · 70 incl. sub-types
13 sub-types
- Malignant testicular germ cell tumor 14 trials · 36 incl. sub-types Sub-types →
- Extragonadal germ cell cancer 0 trials · 22 incl. sub-types Sub-types →
- Seminoma 22 trials Sub-types →
- Germinoma 7 trials · 9 incl. sub-types Sub-types →
- Mixed germ cell tumor 3 trials · 5 incl. sub-types Sub-types →
- Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types Sub-types →
- Malignant childhood germ cell neoplasm 0 trials · 3 incl. sub-types Sub-types →
- Malignant teratoma 1 trial · 3 incl. sub-types Sub-types →
- Dysgerminoma 1 trial Sub-types →
- Malignant germ cell tumor of cervix uteri 0 trials
- Malignant germ cell tumor of corpus uteri 0 trials Sub-types →
- Pulmonary artery choriocarcinoma 0 trials
- Vaginal germ cell malignant tumor 0 trials Sub-types →
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Gonadal germ cell tumor 0 trials · 52 incl. sub-types
3 sub-types
- Testicular germ cell tumor 13 trials · 49 incl. sub-types Sub-types →
- Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types Sub-types →
- Childhood gonadal germ cell tumor 1 trial · 2 incl. sub-types Sub-types →
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Nongerminomatous germ cell tumor 12 trials · 33 incl. sub-types
3 sub-types
- Extragonadal non-dysgerminomatous germ cell tumor 0 trials · 21 incl. sub-types Sub-types →
- Teratoma 6 trials · 10 incl. sub-types Sub-types →
- Malignant non-dysgerminomatous germ cell tumor of ovary 1 trial · 2 incl. sub-types Sub-types →
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Extragonadal germ cell tumor 2 trials · 29 incl. sub-types
6 sub-types
- Extragonadal germ cell cancer 0 trials · 22 incl. sub-types Sub-types →
- Extragonadal non-dysgerminomatous germ cell tumor 0 trials · 21 incl. sub-types Sub-types →
- Central nervous system germ cell tumor 6 trials · 9 incl. sub-types Sub-types →
- Mediastinal germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Cardiac germ cell tumor 0 trials Sub-types →
- Lung germ cell tumor 0 trials
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Germinomatous germ cell tumor 1 trial · 22 incl. sub-types
2 sub-types
- Seminoma 22 trials Sub-types →
- Dysgerminoma 1 trial Sub-types →
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Ovarian germ cell tumor 9 trials · 13 incl. sub-types
4 sub-types
- Malignant germ cell tumor of ovary 2 trials · 4 incl. sub-types Sub-types →
- Ovarian teratoma 0 trials · 3 incl. sub-types Sub-types →
- Pediatric ovarian germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Ovarian cystic teratoma 0 trials Sub-types →
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Childhood germ cell tumor 3 trials · 7 incl. sub-types
4 sub-types
- Malignant childhood germ cell neoplasm 0 trials · 3 incl. sub-types Sub-types →
- Childhood central nervous system germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
- Childhood gonadal germ cell tumor 1 trial · 2 incl. sub-types Sub-types →
- Pediatric ovarian germ cell tumor 0 trials · 2 incl. sub-types Sub-types →
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Choriocarcinoma 4 trials · 5 incl. sub-types
8 sub-types
- Choriocarcinoma of ovary 1 trial Sub-types →
- Choriocarcinoma of testis 1 trial Sub-types →
- Gestational choriocarcinoma 0 trials · 1 incl. sub-types Sub-types →
- Choriocarcinoma of the central nervous system 0 trials Sub-types →
- Gastric choriocarcinoma 0 trials
- Non-gestational choriocarcinoma 0 trials
- Placental site trophoblastic tumor 0 trials
- Pulmonary artery choriocarcinoma 0 trials
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Adult germ cell tumor 0 trials
3 sub-types
- Adult central nervous system germ cell tumor 0 trials Sub-types →
- Adult teratoma 0 trials Sub-types →
- Adult yolk sac tumor 0 trials
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Fallopian tube germ cell tumor 0 trials
2 sub-types
- Fallopian tube gestational choriocarcinoma 0 trials
- Fallopian tube teratoma 0 trials
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Germ cell benign neoplasm 0 trials
1 sub-type
- Benign teratoma 0 trials
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Germ cell tumor of the vulva 0 trials
2 sub-types
- Immature teratoma of vulva 0 trials
- Mixed germ cell tumor of vulva 0 trials
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Retroperitoneal germ cell neoplasm 0 trials
Most studied deeper sub-types
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Experimental CAR T-Cell therapy targets rare testicular cancer
Disease control CompletedThis phase 2 study tested a new treatment for nonseminomatous germ cell tumors (a type of testicular cancer) that had not responded to standard therapy. The treatment used the patient's own immune cells (T cells) that were genetically modified to recognize and attack cancer cells…
Phase 2 • Sponsor: UNC Lineberger Comprehensive Cancer Center • Aim: Disease control
Last updated Jul 09, 2026 00:00 UTC
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New chemo cocktail targets Hard-to-Treat testicular cancer
Disease control CompletedThis study tests a combination of three chemotherapy drugs—gemcitabine, oxaliplatin, and paclitaxel—in people with advanced testicular cancer that has not responded to standard cisplatin-based treatment or has returned after treatment. The goal is to see if this drug combination …
Phase 2 • Sponsor: University of Southern California • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Could a dementia drug shield kids' brains from radiation damage?
Disease control CompletedThis pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 14:02 UTC
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Personalized chemo dosing aims to beat tough testicular cancers
Disease control CompletedThis phase 2 trial tested a high-dose chemotherapy regimen called TICE in 101 patients with germ cell tumors that had relapsed or were not responding to standard treatment. The approach uses two cycles of paclitaxel and ifosfamide followed by three cycles of carboplatin and etopo…
Phase 2 • Sponsor: Institut Claudius Regaud • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New stem cell transplant shows promise for kids with tough cancers
Disease control CompletedThis study tested a new way to do stem cell transplants in 23 children with cancers that came back or didn't respond to treatment. The method removes certain immune cells from the donor's stem cells to help the child's body recover faster and fight infections better. The goal was…
Phase 1 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Immune cells injected directly into brain show promise for kids with tough tumors
Disease control CompletedThis early-stage study tested a new treatment for children and young adults with brain tumors that came back or didn't respond to standard therapy. Doctors took the patients' own immune cells, modified them to recognize a protein called EGFR on tumor cells, and injected them dire…
Phase 1 • Sponsor: Seattle Children's Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:04 UTC
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New hope for kids with rare cancer: sirolimus combo shows promise
Disease control CompletedThis study tested a new combination of drugs (sirolimus plus chemotherapy) in 32 children with recurrent or refractory yolk sac tumors, a rare type of germ cell tumor. The goal was to see if the combination could shrink tumors and improve survival. The treatment was given in cycl…
Phase 2/3 • Sponsor: Shandong First Medical University • Aim: Disease control
Last updated Jun 26, 2026 19:11 UTC
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Old drug, new hope: thalidomide combo shows promise for kids with rare cancer
Disease control CompletedThis completed phase 2 trial tested a combination of thalidomide and three chemotherapy drugs (nab-paclitaxel, gemcitabine, epirubicin) in 20 children with relapsed or refractory yolk sac tumor, a rare germ cell cancer. The goal was to see if this new mix could shrink tumors or l…
Phase 2 • Sponsor: Shandong First Medical University • Aim: Disease control
Last updated Jun 26, 2026 17:46 UTC
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Scientists hunt for testicular cancer genes in families
Knowledge-focused CompletedThis study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …
Sponsor: National Cancer Institute (NCI) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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Can a Child's tumor DNA guide better cancer treatment?
Knowledge-focused CompletedThis study tested whether analyzing the DNA and RNA of a child's tumor could help doctors choose personalized treatments. It included 186 children with relapsed or hard-to-treat cancers like neuroblastoma and brain tumors. The goal was to see if this approach was feasible and saf…
Sponsor: Giselle Sholler • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC