Frontotemporal dementia with motor neuron disease
MONDO:0017161Frontotemporal dementia with motor neuron disease (FTD-MND) is a type of frontotemporal lobar degeneration characterized by the insidious onset (between the ages of 38-78 years) of dementia-associated psychiatric symptoms (e.g. personality changes, uninhibited behavior, irritability, aggressiveness), memory difficulties, global intellectual impairment, emotional disorders and transcortical motor aphasia that eventually leads to mutism, in addition to the manifestations of motor neuron disease such as neurogenic muscular wasting (similar to what is seen in amyotrophic lateral sclerosis). The disease is progressive, with death occurring 2-5 years after onset.
Also known as: FTD-ALS, FTD-MND, FTDALS, frontotemporal dementia with ALS, frontotemporal dementia with amyotrophic lateral sclerosis
31 clinical trials for this condition and its sub-types, 14 tagged with Frontotemporal dementia with motor neuron disease itself.
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Sub-types of Frontotemporal dementia with motor neuron disease
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Gut bacteria trial aims to slow ALS and dementia
Disease control Recruiting nowThis study tests whether a special probiotic supplement can change fat-related molecules in the blood of people with ALS and frontotemporal dementia (FTD). Researchers will compare those taking the probiotic to those taking a placebo over 24 weeks. The goal is to see if the probi…
Sponsor: Centre hospitalier de l'Université de Montréal (CHUM) • Aim: Disease control
Last updated Sep 19, 2026 00:00 UTC
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Brain scan study aims to spot tau protein in rare dementias
Knowledge-focused Recruiting nowThis study uses a special PET scan to measure tau protein buildup in the brains of people with frontotemporal lobar degeneration (FTLD), atypical Alzheimer's disease, and healthy volunteers. Researchers want to see if this scan can help tell these conditions apart. About 72 adult…
Phase 3 • Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Sep 21, 2026 18:00 UTC
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Can tracking brain changes over time unlock the secrets of frontotemporal dementia?
Knowledge-focused Recruiting nowThis long-term study follows people with or at genetic risk for frontotemporal lobar degeneration (FTLD), a group of brain disorders that cause changes in behavior, language, and movement. Researchers will use brain scans, memory tests, and blood samples to measure how the diseas…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Aug 01, 2026 00:00 UTC
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Massive data dive aims to unlock ALS mysteries
Knowledge-focused Recruiting nowThis study gathers information from the medical records of 1,200 people with ALS and similar conditions. Researchers will use this data to better understand the disease and improve future studies. No experimental treatments are given—the goal is simply to learn from real-world pa…
Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Super-Detailed brain scans could reveal early signs of Alzheimer's, Parkinson's, and ALS
Knowledge-focused Recruiting nowThis study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…
Sponsor: Universitaire Ziekenhuizen KU Leuven • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:04 UTC
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Can we catch ALS before it strikes? scientists launch landmark study
Knowledge-focused Recruiting nowThis study follows healthy people who have a family history and genetic risk for ALS. Researchers want to find early warning signs and understand what triggers the disease. Participants do not receive any treatment, but their health is tracked over time. The goal is to learn how …
Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:03 UTC
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Can we stop ALS before it starts? new study tracks families with genetic risk
Knowledge-focused Recruiting nowThis study enrolls family members of people with inherited ALS who do not yet have symptoms. Participants receive genetic counseling and testing, and are followed yearly to track when and how symptoms might appear. The goal is to gather information that could one day lead to trea…
Sponsor: Columbia University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:09 UTC
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Mayo clinic launches biorepository to unlock ALS biomarkers
Knowledge-focused Recruiting nowThis study collects blood and spinal fluid samples from 100 people with ALS or similar neurodegenerative disorders. The samples are stored for future research to find biomarkers that could help understand or diagnose these diseases. Participants include patients and their spouses…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC