Friedreich ataxia
MONDO:0100339An inherited condition that affects the nervous system and causes movement problems. People with this condition develop impaired muscle coordination (ataxia) that worsens over time. Other features include the gradual loss of strength and sensation in the arms and legs, muscle stiffness (spasticity), and impaired speech. Many individuals have a form of heart disease called hypertrophic cardiomyopathy. Some develop diabetes, impaired vision, hearing loss, or an abnormal curvature of the spine (scoliosis). Most people with Friedreich ataxia begin to experience the signs and symptoms around puberty.
Also known as: FA, FRDA, Friedreich ataxia, Friedreich's Ataxia, Friedreich's ataxia, Friedreich ataxia with retained reflexes, hereditary spinal ataxia, hereditary spinal sclerosis
55 clinical trials for this condition and its sub-types, 37 tagged with Friedreich ataxia itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Friedreich ataxia
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Friedreich ataxia 1 1 trial
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Friedreich ataxia 2 0 trials
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Experimental drug aims to halt rare neurological decline
Disease control Not yet recruitingThis Phase 3 trial tests whether vatiquinone can slow the progression of Friedreich's ataxia, a rare genetic disorder that damages the nervous system and impairs movement. About 120 adults with moderate symptoms will take the drug for 24 months. Researchers will measure changes i…
Phase 3 • Sponsor: PTC Therapeutics • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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Exercise and drug combo may fight fatigue in rare disease
Symptom relief Not yet recruitingThis study looks at whether doing aerobic exercise at home, with or without the drug omaveloxolone, can safely improve fatigue and heart-lung fitness in people with Friedreich's ataxia. About 30 adults with the condition will take part. The goal is to see if the combination helps…
Sponsor: Scott Barbuto • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Video games and AI join the fight against a rare movement disorder
Knowledge-focused Not yet recruitingThis study is testing whether a new digital tool—using AI-powered video games and a single camera—can accurately measure movement problems in people with Friedreich ataxia, a rare inherited condition that affects balance and coordination. Participants play short movement-based co…
Sponsor: University of Exeter • Aim: Knowledge-focused
Last updated Jul 30, 2026 00:00 UTC