Fatal familial insomnia
MONDO:0010808Fatal familial insomnia (FFI) is a very rare form of prion disease characterized by subacute onset of insomnia showing as a reduced overall sleep time, autonomic dysfunction, and motor disturbances.
Also known as: fatal familial insomnia, FFI, Insomnia familial fatal, Insomnia, fatal familial, familial fatal insomnia, fatal familial INSOMNIA
28 clinical trials for this condition and its sub-types, 4 tagged with Fatal familial insomnia itself.
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Could a single injection silence fatal brain disease?
Disease control Recruiting nowThis study tests an experimental drug called PrP-siRNA in 30 adults with symptomatic prion disease, a rare and fatal brain condition. The drug is given via a spinal injection and aims to reduce the harmful prion protein in the brain. The main goal is to check safety and find the …
Phase 1 • Sponsor: Broad Institute of MIT and Harvard • Aim: Disease control
Last updated Aug 30, 2026 00:00 UTC
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Scientists hunt for clues to predict rare brain disease before symptoms strike
Knowledge-focused Recruiting nowThis study aims to find biological markers in spinal fluid and blood that could signal the start of prion disease before symptoms appear. Researchers will follow 150 people who carry a genetic mutation for prion disease, along with family members and healthy volunteers. Participa…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Aug 15, 2026 00:00 UTC