Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis

MONDO:0017624

Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a form of familial primary hypomagnesemia (FPH), characterized by renal magnesium (Mg) and calcium (Ca) wasting, nephrocalcinosis, kidney failure and, in some cases, severe ocular impairment. Two subtypes of FHHNC are described: FHHNC with severe ocular involvement (FHHNCOI) and without severe ocular involvement (FHHN).

Also known as: FHHNC, Michellis-Castrillo syndrome

2 clinical trials for this condition and its sub-types, 0 tagged with Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis itself.

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↑ Familial primary hypomagnesemia (5)

Sub-types of Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis

Renal hypomagnesemia 3 1 trial
Renal hypomagnesemia 5 with ocular involvement 0 trials

Including sub-types (2) Tagged with Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis (0)

Trials to join now! 1 Terminated 1

Could a diabetes drug protect kidneys in children with genetic disease?

Disease control Recruiting now

This study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…

Phase 3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control

Last updated Jul 08, 2026 00:00 UTC

Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis

Where it sits in the disease tree

Could a diabetes drug protect kidneys in children with genetic disease?