Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis

MONDO:0017624

Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis (FHHNC) is a form of familial primary hypomagnesemia (FPH), characterized by renal magnesium (Mg) and calcium (Ca) wasting, nephrocalcinosis, kidney failure and, in some cases, severe ocular impairment. Two subtypes of FHHNC are described: FHHNC with severe ocular involvement (FHHNCOI) and without severe ocular involvement (FHHN).

Also known as: FHHNC, Michellis-Castrillo syndrome

1 clinical trial for this condition and its sub-types.

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Sub-types

Renal hypomagnesemia 3 (0) Renal hypomagnesemia 5 with ocular involvement (0)

Broader categories

Disease (680) Metabolic disease (233) Kidney disorder (214) Hereditary disease (176) Urinary system disorder (66) Inborn errors of metabolism (45) Human disease (14) Familial primary hypomagnesemia (4) Disease of genetic or genomic mechanism (2) Inborn metal metabolism disorder (1)

Trials to join now! 1

Could a diabetes drug protect kidneys in children with genetic disease?

Disease control Recruiting now

This study tests whether adding dapagliflozin (a diabetes drug) to standard care reduces protein leakage in the urine of children with hereditary kidney diseases. About 44 children will receive either dapagliflozin plus standard care or standard care alone for 12 weeks, then swit…

Phase: PHASE3 • Sponsor: Children's Hospital of Fudan University • Aim: Disease control

Last updated Jul 08, 2026 00:00 UTC

Familial primary hypomagnesemia with hypercalciuria and nephrocalcinosis

Sub-types

Broader categories

Could a diabetes drug protect kidneys in children with genetic disease?