Familial episodic pain syndrome with predominantly lower limb involvement

MONDO:0014247

A rare, autosomal dominant disorder caused by mutation in the SCN11A gene. It is characterized by intense episodic pain mainly affecting the distal lower extremities in early childhood. The pain diminishes with age.

Also known as: episodic pain syndrome, familial, type 3, FEPS3, episodic pain syndrome, familial, 3

10 clinical trials for this condition and its sub-types, 0 tagged with Familial episodic pain syndrome with predominantly lower limb involvement itself.

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Where it sits in the disease tree

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↑ Syndromic disease (7158) ↑ Familial episodic pain syndrome (0)

Including sub-types (10) Tagged with Familial episodic pain syndrome with predominantly lower limb involvement (0)

Trials to join now! 6 Not yet recruiting 1 Completed 1 Terminated 2

Laser test could objectively measure nerve pain for first time

Diagnosis Completed

This study tested whether a diode laser can act as a biomarker to measure neuropathic pain in people with peripheral neuropathy. Researchers compared pain responses to a lidocaine patch versus a placebo patch in 75 participants. The goal was to see if the laser test could disting…

Sponsor: University of Utah • Aim: Diagnosis

Last updated Jun 27, 2026 12:09 UTC

Familial episodic pain syndrome with predominantly lower limb involvement

Where it sits in the disease tree

Laser test could objectively measure nerve pain for first time