Familial cold autoinflammatory syndrome

MONDO:0018768

Familial cold urticaria (FCAS) is the mildest form of cryopyrin-associated periodic syndrome (CAPS) and is characterized by recurrent episodes of urticaria-like skin rash triggered by exposure to cold associated with low-grade fever, general malaise, eye redness and arthralgia/myalgia.

Also known as: FCAS, FCU, familial cold autoinflammatory syndrome, familial cold urticaria, familial polymorphous cold eruption

15 clinical trials for this condition and its sub-types, 3 tagged with Familial cold autoinflammatory syndrome itself.

Follow this condition to get notified about new trials

Where it sits in the disease tree

Browse by category →

Part of

↑ Cryopyrin-associated periodic syndrome (10)

Sub-types of Familial cold autoinflammatory syndrome

Familial cold autoinflammatory syndrome 1 0 trials
Familial cold autoinflammatory syndrome 2 0 trials
Familial cold autoinflammatory syndrome 3 0 trials
Familial cold autoinflammatory syndrome 4 0 trials

Including sub-types (15) Tagged with Familial cold autoinflammatory syndrome (3)

Trials to join now! 2 Completed 1

Scientists probe genetic roots of Cold-Triggered hives

Knowledge-focused Completed

This study looks at why some people develop hives from physical triggers like cold, pressure, or sunlight. Researchers will test participants' skin reactions and collect blood and genetic samples to understand the role of immune cells and genes. The goal is to uncover the underly…

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) • Aim: Knowledge-focused

Last updated Jun 27, 2026 12:01 UTC

Familial cold autoinflammatory syndrome

Where it sits in the disease tree

Scientists probe genetic roots of Cold-Triggered hives