Familial amyotrophic lateral sclerosis

MONDO:0005144

An instance of amyotrophic lateral sclerosis that is caused by an inherited modification of the individual's genome.

Also known as: hereditary amyotrophic lateral sclerosis

39 clinical trials for this condition and its sub-types, 2 tagged with Familial amyotrophic lateral sclerosis itself.

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Where it sits in the disease tree

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Part of

↑ Amyotrophic lateral sclerosis (341) ↑ Hereditary motor neuron disease (169)

Sub-types of Familial amyotrophic lateral sclerosis

Spinocerebellar ataxia type 2 10 trials
1 sub-type
- Spinocerebellar degeneration with slow eye movements 0 trials
Amyotrophic lateral sclerosis type 1 8 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 1 5 trials
Amyotrophic lateral sclerosis type 10 3 trials
Amyotrophic lateral sclerosis type 4 1 trial
Amyotrophic lateral sclerosis type 6 1 trial
Amyotrophic lateral sclerosis type 7 1 trial
Amyotrophic lateral sclerosis 26 with or without frontotemporal dementia 0 trials
Amyotrophic lateral sclerosis 27, juvenile 0 trials
Amyotrophic lateral sclerosis 28 0 trials
Amyotrophic lateral sclerosis type 11 0 trials
Amyotrophic lateral sclerosis type 12 0 trials
Amyotrophic lateral sclerosis type 15 0 trials
Amyotrophic lateral sclerosis type 18 0 trials
Amyotrophic lateral sclerosis type 19 0 trials
Amyotrophic lateral sclerosis type 20 0 trials
Amyotrophic lateral sclerosis type 21 0 trials
Amyotrophic lateral sclerosis type 22 0 trials
Amyotrophic lateral sclerosis type 23 0 trials
Amyotrophic lateral sclerosis type 3 0 trials
Amyotrophic lateral sclerosis type 8 0 trials
Amyotrophic lateral sclerosis type 9 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 2 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 3 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 4 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 5 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 6 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 7 0 trials
Frontotemporal dementia and/or amyotrophic lateral sclerosis 8 0 trials
Juvenile amyotrophic lateral sclerosis 0 trials
4 sub-types
- Amyotrophic lateral sclerosis type 16 0 trials
- Amyotrophic lateral sclerosis type 2, juvenile 0 trials
- Amyotrophic lateral sclerosis type 5 0 trials
- Juvenile amyotrophic lateral sclerosis with dementia 0 trials

Including sub-types (39) Tagged with Familial amyotrophic lateral sclerosis (2)

Trials to join now! 1 Not yet finished but already full! 1

New hope for ALS: first human trial of Gene-Targeting drug begins

Disease control Recruiting now

This study tests an experimental drug called ALN-SOD in people with ALS caused by a mutation in the SOD1 gene. The drug is given via spinal injection to target the root cause of the disease. The main goal is to check safety, but researchers will also measure effects on biomarkers…

Phase 1/2 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control

Last updated Sep 13, 2026 00:00 UTC

Familial amyotrophic lateral sclerosis

Where it sits in the disease tree

New hope for ALS: first human trial of Gene-Targeting drug begins