Ewing sarcoma/peripheral primitive neuroectodermal tumor
MONDO:0021038A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells. Ewing sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor. Ewing sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities. These tumors may occur in the soft tissues or the bones. Pain and the presence of a mass are the most common clinical symptoms.
Also known as: EFTs, Ewing family of tumors, Ewing family of tumours, Ewing sarcoma family of tumors, Ewing sarcoma family of tumours, Ewing sarcoma/peripheral PNET, Ewing sarcoma/peripheral primitive neuroectodermal tumor, Ewing's family of tumors
1564 clinical trials for this condition and its sub-types, 7 tagged with Ewing sarcoma/peripheral primitive neuroectodermal tumor itself.
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Sub-types of Ewing sarcoma/peripheral primitive neuroectodermal tumor
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Ewing sarcoma 124 trials · 125 incl. sub-types
2 sub-types
- Ewing sarcoma of bone 5 trials
- Extraskeletal Ewing sarcoma 3 trials
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Central nervous system Ewing sarcoma/peripheral primitive neuroectodermal tumor 1 trial · 22 incl. sub-types
4 sub-types
- Esthesioneuroblastoma 9 trials
- Embryonal tumor with multilayered rosettes 8 trials
- Ependymoblastoma 5 trials Sub-types →
- Medulloepithelioma 3 trials
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Peripheral primitive neuroectodermal tumor 7 trials · 8 incl. sub-types
3 sub-types
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Ewing sarcoma/peripheral primitive neuroectodermal tumor of bone 0 trials · 7 incl. sub-types
2 sub-types
- Ewing sarcoma of bone 5 trials
- Peripheral primitive neuroectodermal tumor of bone 3 trials
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Extraskeletal Ewing sarcoma/peripheral primitive neuroectodermal tumor 0 trials · 4 incl. sub-types
2 sub-types
Most studied deeper sub-types
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New hope for tough childhood cancers: targeted drug combo under study
Disease control CompletedThis study tests a new combination of drugs (temsirolimus, temozolomide, and irinotecan) for children and young adults with high-risk Ewing sarcoma or desmoplastic small round cell tumors. Participants are split into standard-risk and high-risk groups, with high-risk patients rec…
Phase 2 • Sponsor: St. Jude Children's Research Hospital • Aim: Disease control
Last updated Aug 23, 2026 00:00 UTC
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New hope for kids with Hard-to-Treat cancers: targeted drug shows promise
Disease control CompletedThis study tested a drug called tazemetostat in 20 children whose cancers had come back or weren't responding to treatment. The children had specific gene changes (EZH2, SMARCB1, or SMARCA4) in their tumors. The goal was to see if the drug could shrink or slow the growth of these…
Phase 2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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New chemo cocktail shows promise for rare bone cancer
Disease control CompletedThis study tested a more intense chemotherapy plan for people aged 2 to 50 with Ewing sarcoma that has spread beyond the lungs. The goal was to see if this approach could help more patients become cancer-free for at least 18 months. The treatment combined high-dose chemotherapy w…
Phase 2 • Sponsor: Institut Curie • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC