Endomyocardial fibrosis
MONDO:0006746A disease characterized by fibrotic thickening of the endocardium, particularly the right and/or left inflow tracts. The disease often involves the atrioventricular valves, leading to valvular regurgitaion. It most commonly occurs in children living within 15 degrees of the equator.
Also known as: African endomyocardial fibrosis
24 clinical trials for this condition and its sub-types, 16 tagged with Endomyocardial fibrosis itself.
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Triple drug combo aims to reverse heart scarring in stiff heart failure
Disease control Recruiting nowThis study tests whether a three-drug combination (SGLT2 inhibitor, ARNI, and MRA) can improve heart structure, function, and symptoms in 50 people with advanced HFpEF, a type of heart failure where the heart is stiff but pumps normally. Participants will receive either the tripl…
Phase 2 • Sponsor: National Medical Research Center for Cardiology, Ministry of Health of Russian Federation • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Gene therapy trial aims to fix heart damage in rare disease
Disease control Recruiting nowThis early-stage trial tests a gene therapy called AAVrh.10hFXN for heart problems caused by Friedreich's ataxia, a rare genetic disease. The therapy delivers a working copy of the frataxin gene to help heart cells function better. 25 people aged 12 to 50 with heart involvement w…
Phase 1 • Sponsor: Weill Medical College of Cornell University • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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One scan to rule them all? new CT aims to replace multiple heart tests
Diagnosis Recruiting nowThis study tests whether a newer type of CT scan, called photon-counting CT, can accurately measure blood flow to the heart muscle and detect scarring or fibrosis. Researchers will compare the CT results with cardiac MRI and invasive coronary angiography in 100 patients with aort…
Sponsor: Karolinska University Hospital • Aim: Diagnosis
Last updated Sep 04, 2026 00:00 UTC
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New contrast agent could mean lower doses for heart MRI
Diagnosis Recruiting nowThis study tests whether a new MRI contrast agent called Elucirem can detect heart scarring as effectively as the standard agent, but at a much lower dose. Researchers will compare images from 25 adults who previously had a heart MRI with the standard agent. If Elucirem works wel…
Phase 4 • Sponsor: Johns Hopkins University • Aim: Diagnosis
Last updated Jun 27, 2026 12:06 UTC
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Heart MRI breakthrough could spot hidden risks in thousands
Knowledge-focused Recruiting nowThis study is testing whether a detailed heart MRI (called T1 mapping) can better predict who will develop heart disease, heart failure, or long COVID complications. Researchers will scan 6000 adults without known heart disease and follow them over time. The goal is to see if sub…
Sponsor: Johann Wolfgang Goethe University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:08 UTC
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New PET scan could reveal hidden heart scarring in real time
Knowledge-focused Recruiting nowThis pilot study is testing a new type of PET/CT scan that uses a radioactive tracer called 68Ga-FAPI to detect active scarring (fibrosis) in the hearts of 30 people with heart failure. The goal is to see if this scan can spot early or ongoing scarring better than current MRI met…
Sponsor: University of Coimbra • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC