Endomyocardial fibrosis
MONDO:0006746A disease characterized by fibrotic thickening of the endocardium, particularly the right and/or left inflow tracts. The disease often involves the atrioventricular valves, leading to valvular regurgitaion. It most commonly occurs in children living within 15 degrees of the equator.
Also known as: African endomyocardial fibrosis
24 clinical trials for this condition and its sub-types, 16 tagged with Endomyocardial fibrosis itself.
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Can a common heart drug reverse scarring in stiff heart failure?
Disease control CancelledThis study tests whether the drug sacubitril/valsartan can reduce scarring in the heart muscle of people with a type of heart failure called HFpEF (stiff heart). The trial will enroll 36 adults aged 50 and older with heart failure and a normal pumping function. Participants will …
Phase 4 • Sponsor: Brigham and Women's Hospital • Aim: Disease control
Last updated Sep 02, 2026 00:00 UTC
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Could a gout drug tame high blood pressure?
Disease control OngoingThis study tests whether colchicine, a drug used for gout, can improve blood vessel stiffness and heart function in people with high blood pressure. About 150 adults with hypertension and additional risks like diabetes or high cholesterol will take colchicine or a placebo daily f…
Phase 2 • Sponsor: Herlev and Gentofte Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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New study aims to find gentler radiation for breast cancer Patients' hearts
Knowledge-focused OngoingThis study compares two types of radiation therapy for left-sided breast cancer: proton beam therapy and conventional photon therapy. The goal is to see which one causes fewer changes to the heart, measured by MRI scans. About 60 adults with non-metastatic breast cancer will part…
Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC