Endometrial serous adenocarcinoma
MONDO:0006196A high grade, aggressive adenocarcinoma arising from the endometrium. It is characterized by the presence of complex papillary patterns with cellular budding. Atypical mitoses, necrosis, and psammoma bodies may be present. It is classified as type II endometrial carcinoma and it is not associated with endometrial hyperplasia. It tends to invade deeply into the myometrium and spreads into the lymphatic vessels. Patients frequently present with spread of the tumor beyond the uterus at the time of diagnosis. The prognosis is usually poor.
Also known as: uterine serous adenocarcinoma, uterine serous carcinoma, body of uterus serous adenocarcinoma, endometrial serous adenocarcinoma, serous endometrial adenocarcinoma, uterine corpus serous adenocarcinoma, uterine papillary serous carcinoma, uterine serous papillary adenocarcinoma
2882 clinical trials for this condition and its sub-types, 36 tagged with Endometrial serous adenocarcinoma itself.
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New cancer drug debio 0123 tested in early trial
Disease control Stopped earlyThis early-stage study tested a new drug called Debio 0123 in 66 adults with advanced solid tumors that had stopped responding to standard treatments. The main goals were to find the safest dose and to check for side effects and any signs that the drug could shrink tumors. The st…
Phase 1 • Sponsor: Debiopharm International SA • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Common diabetes and acne drugs tested against cancer
Disease control Stopped earlyThis phase 2 trial tested whether combining metformin (a diabetes drug) with doxycycline (an antibiotic) could help treat localized breast and uterine cancers. The study enrolled 29 people who were scheduled for surgery. Researchers looked at changes in certain proteins in the tu…
Phase 2 • Sponsor: Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Newer radiation technique may spare bladder and bowel in endometrial cancer patients
Symptom relief Stopped earlyThis trial compared two ways of giving pelvic radiotherapy after surgery for endometrial cancer: standard 3D planning versus a newer technique called IMRT. The goal was to see if IMRT could reduce side effects like bladder and bowel problems. The study enrolled 92 participants bu…
Phase 2 • Sponsor: Cancer Trials Ireland • Aim: Symptom relief
Last updated Jun 27, 2026 12:06 UTC