Dysthymic disorder

This Phase 3 study tests whether adding NBI-1065845 to standard antidepressants can delay the return of depressive symptoms in adults with major depression. About 550 people who have not fully responded to current antidepressants will take either the study drug or a placebo pill.…

This study tests whether a multi-strain probiotic called Visbiome can change brain activity and gut bacteria in people aged 15 to 24 with depression. Participants take either the probiotic or a placebo powder daily for several weeks. Researchers use brain scans and stool samples …

This study tests a new way of caring for new mothers and their babies together, called MOMI PODS. It focuses on moms who had heart or mental health problems during pregnancy. The goal is to see if this coordinated care model improves health and reduces risks like postpartum depre…

This phase 2 trial at MD Anderson Cancer Center is testing whether psilocybin-assisted psychotherapy can safely help ease depression and anxiety in 30 adults with advanced cancer who are on maintenance therapy. Participants receive either psilocybin or a placebo (niacin) along wi…

This study tests whether short, computer-based cognitive training sessions can enhance or extend the rapid antidepressant effects of ketamine or esketamine. Researchers will enroll 600 adults with depression who are already receiving ketamine treatment. Participants will do eithe…

This study tests whether psilocybin, the active ingredient in magic mushrooms, combined with talk therapy can safely help cancer survivors with depression or anxiety. Twenty adults who have finished cancer treatment and have no brain involvement will receive a single dose of psil…

This Phase 3 trial tests whether adding NBI-1065845 to standard antidepressants can better ease depression symptoms in 200 adults who haven't fully responded to current treatments. Participants take the drug or a placebo for 8 weeks, and doctors measure changes in mood and daily …

This Phase 3 trial is testing whether an experimental drug called NBI-1065845 can help reduce depression symptoms in adults who haven't responded well to standard antidepressants. About 200 participants will take either the drug or a placebo alongside their current antidepressant…

This Phase 3 study is testing the long-term safety of an experimental drug called NBI-1065845 (TAK-653) in 850 adults with major depressive disorder who haven't gotten enough relief from standard antidepressants. Participants take the drug alongside their usual antidepressant for…

This study compares two types of talk therapy—CBASP and Behavioral Activation—for adults with long-lasting depression that hasn't improved with other treatments. About 396 inpatients will receive 16 weeks of one therapy to see which works better and why. The goal is to find more …

This study tests whether an AI-guided cognitive behavioral therapy program can reduce symptoms of mild depression and anxiety in adults. Over 10 weeks, 120 participants will either receive AI-guided therapy through a digital platform or standard care. The goal is to see if AI can…

This study compares a blended group therapy (online and in-person sessions) to standard in-person group therapy for adults with anxiety or depression. About 144 participants will receive 16 weeks of treatment. The goal is to see if the blended approach works as well and is accept…

This study tests whether an 8-week mindful self-compassion program can reduce symptoms of anxiety and depression. It compares attending the program in person versus through videoconference. The study involves 80 adults diagnosed with anxiety disorders or major depression who also…

This study tests if adding structured exercise to a brain stimulation treatment called iTBS can help people with depression that hasn't improved with medication. Twenty physically inactive adults with difficult-to-treat depression will either get iTBS alone or iTBS plus exercise.…

This study tests a digital program called UKADO for people waiting for face-to-face therapy for depression or anxiety. About 312 adults will try different versions of the program—some focused on problems, others on strengths—with or without human support. The goal is to see which…

This study tests whether adding NBI-1065845 to standard antidepressants can better relieve depression symptoms in adults who haven't gotten enough help from their current medication. About 200 participants will receive either the study drug or a placebo for 8 weeks. The main goal…

This study tests a type of talk therapy called schema therapy for people whose depression has lasted a long time or hasn't gotten better with medication. 129 participants will either get 30 sessions of schema therapy or standard psychotherapy. The goal is to see if schema therapy…

This study compares brain activity and parenting styles in children aged 7-12 with and without depression. It then tests whether these factors can predict how well a child responds to a 12-session family-focused therapy designed to build positive interactions and coping skills. P…

This study is testing a new family-based program (Fam-AID) for teens aged 13-21 who are getting treatment for substance use and also have anxiety or depression. The program adds extra support for mental health and family involvement to their usual care. Researchers want to see if…

This study tests whether using a life history calendar—a simple grid that helps people recall important life events—can improve the accuracy of mental health surveys. Researchers in Hong Kong will ask 2,500 adults about their mental health using either a standard interview or one…

Latino teens are less likely to get depression treatment than their peers. This study asks teens, parents, and doctors which of three strategies—peer support groups, parent-teen training, or care navigation—they prefer. Researchers will interview 15 teens, 15 parents, and 5 healt…