Dysplasia of the proximal femoral epiphyses

MONDO:1030002

A developmental disorder affecting the growth and development of the proximal end of the femur (thigh bone) near the hip joint characterized by avascular necrosis of the femoral head, cystic changes of the femoral head, and/or sclerosis of the femoral head. It is a relatively milder form of the other skeletal disorders associated with COL2A1.

37 clinical trials for this condition and its sub-types, 0 tagged with Dysplasia of the proximal femoral epiphyses itself.

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Where it sits in the disease tree

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Part of

↑ Type 2 collagenopathy (39)

Sub-types of Dysplasia of the proximal femoral epiphyses

Avascular necrosis of femoral head, primary, 1 34 trials
Legg-Calve-Perthes disease 9 trials
Mild spondyloepiphyseal dysplasia due to COL2A1 mutation with early-onset osteoarthritis 0 trials

Including sub-types (37) Tagged with Dysplasia of the proximal femoral epiphyses (0)

Trials to join now! 12 Not yet recruiting 1 Not yet finished but already full! 18 Completed 4 Terminated 2

Oxygen therapy may boost hip procedure for bone death

Disease control Not yet recruiting

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to a standard hip procedure (core decompression with bone marrow cells) can reduce pain in people with early-stage avascular necrosis of the hip. The trial will enroll 400 p…

Sponsor: Yale University • Aim: Disease control

Last updated Jul 03, 2026 00:00 UTC

Dysplasia of the proximal femoral epiphyses

Where it sits in the disease tree

Oxygen therapy may boost hip procedure for bone death