Dyspepsia

MONDO:0002268

An uncomfortable, often painful feeling in the stomach, resulting from impaired digestion. Symptoms include burning stomach pain, bloating, heartburn, nausea, and vomiting. Causes include gastritis, gastric ulcer, gastroesophageal reflux disease, pancreatic disease, and gallbladder disease.

Also known as: dyspepsia, indigestion, indigestion

98 clinical trials for this condition and its sub-types, 97 tagged with Dyspepsia itself.

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Where it sits in the disease tree

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Part of

↑ Functional gastric disease (213)

Including sub-types (98) Tagged with Dyspepsia (97)

Trials to join now! 45 Not yet recruiting 16 Not yet finished but already full! 10 Completed 25 Terminated 1

Can an antidepressant soothe stomach pain?

Symptom relief Stopped early

This trial tests whether nortriptyline, an antidepressant, can reduce abdominal pain and improve quality of life in people with nonulcer dyspepsia—a condition causing stomach discomfort without an ulcer. Participants take either nortriptyline or a placebo capsule nightly for 8 we…

Sponsor: The Cleveland Clinic • Aim: Symptom relief

Last updated Aug 27, 2026 00:00 UTC

Dyspepsia

Where it sits in the disease tree

Can an antidepressant soothe stomach pain?