Disease related to transplantation

This study tests whether giving the drug ruxolitinib early can prevent severe graft-versus-host disease (GvHD) in people getting a stem cell transplant. About 438 adults at intermediate-to-high risk, as identified by a special model called daGOAT, will be enrolled. The goal is to…

This study tests a new approach for people with relapsed or refractory acute myeloid leukemia (AML) who have active disease. Before a stem cell transplant, patients receive a radioactive antibody (131I-apamistamab) along with chemotherapy and low-dose radiation to prepare the bod…

This study will follow 85 adults receiving stem cell transplants to track a serious but often missed complication called TA-TMA. Researchers want to find out how common it is and how it affects survival. Participants will provide blood samples and have standard follow-up care.

This study looks at whether testing the liquid used to preserve donor livers and kidneys can predict infections in recipients. Researchers will check if bacteria or fungi in that fluid match infections that develop after transplant. The goal is to see if this simple test could he…

This study will follow 4,000 people who had a stem cell transplant and later became critically ill, requiring intensive care. Researchers will collect information on their health, treatments, and survival. The goal is to learn more about what happens to these patients and how to …

This study will analyze the DNA and chemical marks on DNA of 200 children who have had a liver or kidney transplant. Researchers want to find genetic clues that might explain why some children develop serious complications like organ rejection, infections, or cancer after transpl…