Digestive system carcinoma
MONDO:0006181A malignant neoplasm that arises from the epithelium of any part of the digestive system. Representative examples include colorectal carcinoma, esophageal carcinoma, and pancreatic carcinoma.
Also known as: carcinoma of digestive system, carcinoma of the gastrointestinal system, digestive system carcinoma, gastrointestinal carcinoma, gastrointestinal carcinoma (disease), gastrointestinal system carcinoma
7486 clinical trials for this condition and its sub-types, 25 tagged with Digestive system carcinoma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system carcinoma
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Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,455 incl. sub-types
7 sub-types
- Hepatocellular carcinoma 1,043 trials · 1,088 incl. sub-types Sub-types →
- Bile duct carcinoma 20 trials · 451 incl. sub-types Sub-types →
- Liver neuroendocrine carcinoma 3 trials Sub-types →
- Undifferentiated carcinoma of liver and intrahepatic biliary tract 1 trial
- Biliary cystadenocarcinoma 0 trials
- Liver carcinoma in situ 0 trials Sub-types →
- Squamous cell carcinoma of liver and intrahepatic biliary tract 0 trials Sub-types →
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Colorectal carcinoma 305 trials · 1,166 incl. sub-types
4 sub-types
- Colorectal adenocarcinoma 246 trials · 546 incl. sub-types Sub-types →
- Rectal carcinoma 54 trials · 392 incl. sub-types Sub-types →
- Colon carcinoma 277 trials · 377 incl. sub-types Sub-types →
- Colorectal squamous cell carcinoma 1 trial · 54 incl. sub-types Sub-types →
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Exocrine pancreatic carcinoma 205 trials · 1,033 incl. sub-types
8 sub-types
- Pancreatic adenocarcinoma 493 trials · 926 incl. sub-types Sub-types →
- Squamous cell carcinoma of pancreas 3 trials · 13 incl. sub-types Sub-types →
- Familial pancreatic carcinoma 9 trials
- Pancreatic carcinoma with mixed differentiation 3 trials
- Pancreatic intraductal papillary-mucinous carcinoma 0 trials · 2 incl. sub-types Sub-types →
- Pancreatic mucinous cystadenoma 1 trial
- Pancreatic large cell neuroendocrine carcinoma 0 trials
- Solid pseudopapillary carcinoma of pancreas 0 trials
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Gastric carcinoma 92 trials · 554 incl. sub-types
12 sub-types
- Gastric adenocarcinoma 448 trials · 480 incl. sub-types Sub-types →
- Gastric cardia carcinoma 3 trials · 7 incl. sub-types Sub-types →
- Hereditary gastric cancer 1 trial · 6 incl. sub-types Sub-types →
- Gastric squamous cell carcinoma 4 trials Sub-types →
- Stomach carcinoma in situ 4 trials Sub-types →
- Epstein-Barr virus-associated gastric carcinoma 1 trial
- Gastric body carcinoma 1 trial Sub-types →
- Undifferentiated carcinoma of stomach 1 trial
- Carcinoma of stomach, salivary gland type 0 trials
- Gastric fundus carcinoma 0 trials Sub-types →
- Gastric pylorus carcinoma 0 trials
- Gastric small cell neuroendocrine carcinoma 0 trials
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Gastroesophageal junction adenocarcinoma 506 trials
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Carcinoma of esophagus 75 trials · 504 incl. sub-types
5 sub-types
- Esophageal squamous cell carcinoma 303 trials · 304 incl. sub-types Sub-types →
- Esophageal adenocarcinoma 168 trials · 172 incl. sub-types Sub-types →
- Esophagus carcinoma in situ 13 trials
- Esophageal small cell neuroendocrine carcinoma 2 trials
- Carcinoma of esophagus, salivary gland type 0 trials
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Carcinoma of pharynx 3 trials · 455 incl. sub-types
6 sub-types
- Oropharyngeal carcinoma 99 trials · 242 incl. sub-types Sub-types →
- Nasopharyngeal carcinoma 210 trials · 211 incl. sub-types Sub-types →
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Hypopharyngeal carcinoma 35 trials · 86 incl. sub-types Sub-types →
- Pharynx carcinoma in situ 0 trials · 2 incl. sub-types Sub-types →
- Pharyngeal adenoid cystic carcinoma 0 trials
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Oral cavity carcinoma 16 trials · 200 incl. sub-types
9 sub-types
- Oral cavity squamous cell carcinoma 139 trials · 154 incl. sub-types Sub-types →
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Tongue carcinoma 4 trials
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Carcinoma of hard palate 1 trial
- Carcinoma of soft palate 1 trial
- Intraoral basal cell carcinoma 0 trials
- Oral cavity mucoepidermoid carcinoma 0 trials Sub-types →
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Small intestine carcinoma 19 trials · 105 incl. sub-types
3 sub-types
- Carcinoma of duodenum 21 trials · 75 incl. sub-types Sub-types →
- Small intestine adenocarcinoma 18 trials · 60 incl. sub-types Sub-types →
- Squamous cell carcinoma of the small intestine 1 trial Sub-types →
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Gallbladder carcinoma 40 trials · 48 incl. sub-types
5 sub-types
- Gallbladder adenocarcinoma 9 trials Sub-types →
- Gall bladder carcinoma in situ 0 trials
- Gallbladder small cell neuroendocrine carcinoma 0 trials
- Gallbladder squamous cell carcinoma 0 trials Sub-types →
- Undifferentiated gallbladder carcinoma 0 trials
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Intestine carcinoma in situ 0 trials · 16 incl. sub-types
2 sub-types
- Rectum carcinoma in situ 1 trial · 13 incl. sub-types Sub-types →
- Colon carcinoma in situ 3 trials Sub-types →
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Pancreatic endocrine carcinoma 12 trials
2 sub-types
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Digestive system mixed adenoneuroendocrine carcinoma 0 trials · 3 incl. sub-types
1 sub-type
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Carcinoma of floor of mouth 1 trial · 2 incl. sub-types
2 sub-types
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Maxillary sinus carcinoma 1 trial · 2 incl. sub-types
3 sub-types
- Maxillary sinus squamous cell carcinoma 1 trial
- Maxillary sinus adenocarcinoma 0 trials
- Maxillary sinus adenoid cystic carcinoma 0 trials
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Ameloblastic carcinoma 0 trials
Most studied deeper sub-types
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Tailored chemo doses could boost GI cancer treatment
Disease control Recruiting nowThis study tests a new way to give chemotherapy for gastrointestinal cancers like colorectal and stomach cancer. Doctors will adjust the dose of one chemo drug (5-FU) based on how well each patient tolerates it, aiming to give higher doses to those who can handle it without sever…
Sponsor: Dartmouth-Hitchcock Medical Center • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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New drug combo targets Hard-to-Treat cancers
Disease control Recruiting nowThis early-phase study tests a new drug called HC010 combined with chemotherapy in people with advanced solid tumors that have spread or cannot be removed. The main goal is to find a safe dose and check for side effects. About 331 participants will join, and researchers will also…
Phase 1 • Sponsor: HC Biopharma Inc. • Aim: Disease control
Last updated Jun 27, 2026 11:02 UTC
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New PET scan technique could sharpen cancer detection in the gut
Diagnosis Recruiting nowThis study is testing a new type of PET scan that uses special probes to highlight digestive system cancers, such as stomach, liver, colon, and pancreatic cancers. Researchers will enroll 400 adults to see how well this imaging method finds tumors and tracks their response to tre…
Sponsor: RenJi Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 08:07 UTC
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Right care, right time: study tests smart palliative care model for heart failure and cancer
Symptom relief Recruiting nowThis study tests a flexible palliative care program for people with advanced heart failure or certain cancers. The program adds more team members—like a social worker or nurse—as symptoms get worse. The goal is to improve quality of life and match care to each person's changing n…
Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Symptom relief
Last updated Sep 16, 2026 00:00 UTC
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New adaptive palliative care model aims to give right care at the right time
Symptom relief Recruiting nowThis study tests a home-based palliative care program called TIER-PC that adjusts the care team based on a patient's symptoms and ability to function. It includes 60 adults with advanced heart failure or certain cancers living in Manhattan. The program adds more specialists—like …
Sponsor: Icahn School of Medicine at Mount Sinai • Aim: Symptom relief
Last updated Jul 17, 2026 00:00 UTC
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Can ER talks ease cancer suffering? new study aims to find out
Symptom relief Recruiting nowThis study tests whether training emergency room doctors in palliative care can improve quality of life for patients with advanced lung or gastrointestinal cancer. About 200 participants will be split into two groups: one gets standard ER care, the other gets care from a doctor t…
Sponsor: M.D. Anderson Cancer Center • Aim: Symptom relief
Last updated Jul 16, 2026 00:00 UTC
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Gut bacteria may hold key to better cancer therapy
Knowledge-focused Recruiting nowThis study investigates whether the unique bacteria found inside digestive system tumors can help predict how well a patient will respond to neoadjuvant therapy (chemotherapy before surgery). Researchers will analyze tumor samples from 90 adults with pancreatic, gastric, colorect…
Sponsor: Tianjin Medical University Cancer Institute and Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study aims to uncover cancer genes in underrepresented populations
Knowledge-focused Recruiting nowThis study is looking at how cancer genetic testing works in people from different ethnic backgrounds. Researchers will collect blood samples and genetic information from 1,800 adults with various solid tumors. The goal is to find cancer-related gene mutations and see if current …
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC