Diffuse intrinsic pontine glioma
MONDO:0006033A neuroglial tumor that arises from the middle portion of the brain stem. It usually affects children and has a poor prognosis.
Also known as: DIPG, diffuse midline glioma, infiltrative brainstem glioma
3135 clinical trials for this condition and its sub-types, 82 tagged with Diffuse intrinsic pontine glioma itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Diffuse intrinsic pontine glioma
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Diffuse midline glioma, H3 K27-altered 11 trials · 39 incl. sub-types
1 sub-type
- Diffuse midline glioma, H3 K27M-mutant 31 trials
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Engineered immune cells take on deadly brain tumors
Disease control Stopped earlyThis early-phase study tests a new treatment for glioblastoma, an aggressive brain cancer. The approach uses a patient's own immune cells, modified in the lab to better recognize and attack the tumor, combined with chemotherapy. The main goal is to check the safety of this therap…
Phase 1 • Sponsor: Shenzhen Geno-Immune Medical Institute • Aim: Disease control
Last updated Aug 26, 2026 00:00 UTC
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New drug combo shows promise for kids with brain cancer
Disease control Stopped earlyThis early-phase trial is testing two drugs, avelumab and lenvatinib, together in children with brain tumors that have not responded to prior treatment. The study has two parts: first, finding a safe dose, and second, seeing if the combination can slow tumor growth. Only 17 child…
Phase 1 • Sponsor: EMD Serono Research & Development Institute, Inc. • Aim: Disease control
Last updated Jul 31, 2026 00:00 UTC
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Experimental cell therapy targets deadly childhood brain cancer
Disease control Stopped earlyThis early-phase trial tested a new immunotherapy approach for children with DIPG, a rare and aggressive brain stem tumor. After standard radiation and chemotherapy, patients received special vaccines and immune cells designed to attack the tumor. The study was small (11 particip…
Phase 1 • Sponsor: University of Florida • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC